• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用新型基因组序列破译鳍足类动物的进化特征：Phoca largha、Callorhinus ursinus 和 Eumetopias jubatus 的首个基因组。

Deciphering the evolutionary signatures of pinnipeds using novel genome sequences: The first genomes of Phoca largha, Callorhinus ursinus, and Eumetopias jubatus.

机构信息

Biotechnology Research Division, National Institute of Fisheries Science, 216 Haean-ro, Gijang-eup, Gijang gun, Busan, 46083, Republic of Korea.

Interdisciplinary Program in Bioinformatics, Seoul National University, Kwan-ak Gu, Seoul, Republic of Korea.

出版信息

Sci Rep. 2018 Nov 15;8(1):16877. doi: 10.1038/s41598-018-34758-0.

DOI:10.1038/s41598-018-34758-0
PMID:30442995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6237890/
Abstract

The pinnipeds, which comprise seals, sea lions, and walruses, are a remarkable group of marine animals with unique adaptations to semi-aquatic life. However, their genomes are poorly characterized. In this study, we sequenced and characterized the genomes of three pinnipeds (Phoca largha, Callorhinus ursinus, and Eumetopias jubatus), focusing on site-wise sequence changes. We detected rapidly evolving genes in pinniped lineages and substitutions unique to pinnipeds associated with amphibious sound perception. Phenotypic convergence-related sequence convergences are not common in marine mammals. For example, FASN, KCNA5, and IL17RA contain substitutions specific to pinnipeds, yet are potential candidates of phenotypic convergence (blubber, response to hypoxia, and immunity to pathogens) in all marine mammals. The outcomes of this study will provide insight into targets for future studies of convergent evolution or gene function.

摘要

鳍足类动物包括海豹、海狮和海象，是一群适应半水生生活的非凡海洋动物。然而，它们的基因组特征尚未得到充分的描述。在这项研究中，我们对三种鳍足类动物（斑海豹、髯海豹和港湾海豹）的基因组进行了测序和特征描述，重点关注了位点特异性序列变化。我们检测到了鳍足类谱系中快速进化的基因，以及与两栖声音感知相关的鳍足类特有的替代。表型趋同相关的序列趋同并不常见于海洋哺乳动物中。例如，FASN、KCNA5 和 IL17RA 包含鳍足类特有的替代，然而它们是所有海洋哺乳动物中表型趋同（脂肪、对缺氧的反应和对病原体的免疫）的潜在候选基因。这项研究的结果将为未来的趋同进化或基因功能研究提供有价值的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/d2ecc45fd7b5/41598_2018_34758_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/4ff1bed10580/41598_2018_34758_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/659207424ad4/41598_2018_34758_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/d2ecc45fd7b5/41598_2018_34758_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/4ff1bed10580/41598_2018_34758_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/659207424ad4/41598_2018_34758_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae96/6237890/d2ecc45fd7b5/41598_2018_34758_Fig3_HTML.jpg

相似文献

1
Deciphering the evolutionary signatures of pinnipeds using novel genome sequences: The first genomes of Phoca largha, Callorhinus ursinus, and Eumetopias jubatus.利用新型基因组序列破译鳍足类动物的进化特征：Phoca largha、Callorhinus ursinus 和 Eumetopias jubatus 的首个基因组。
Sci Rep. 2018 Nov 15;8(1):16877. doi: 10.1038/s41598-018-34758-0.
2
CARDIAC EXAMINATIONS OF ANESTHETIZED STELLER SEA LIONS (), NORTHERN FUR SEALS (), AND A WALRUS ().麻醉状态下的北方海象、髯海豹和海象的心脏检查。
J Zoo Wildl Med. 2021 Jun;52(2):507-519. doi: 10.1638/2020-0054.
3
Feeding kinematics and performance of basal otariid pinnipeds, Steller sea lions and northern fur seals: implications for the evolution of mammalian feeding.基础海狗科鳍足类动物、北海狮和北海狗的进食运动学与进食表现：对哺乳动物进食进化的启示
J Exp Biol. 2015 Oct;218(Pt 20):3229-40. doi: 10.1242/jeb.126573. Epub 2015 Oct 8.
4
Differentiating between Steller sea lion (Eumetopias jubatus) and northern fur seal (Callorhinus ursinus) scats through analysis of faecal DNA.通过粪便 DNA 分析区分北方海狗（Callorhinus ursinus）和北象海豹（Eumetopias jubatus）的粪便。
Mol Ecol Resour. 2011 Jan;11(1):166-70. doi: 10.1111/j.1755-0998.2010.02874.x.
5
Vanadium accumulation in pinnipeds.鳍足类动物体内的钒积累。
Arch Environ Contam Toxicol. 1999 Jan;36(1):81-6. doi: 10.1007/s002449900445.
6
Occurrence of Pasteurellaceae bacteria in the oral cavity of selected marine mammal species.特定海洋哺乳动物物种口腔中巴斯德氏菌科细菌的存在情况。
J Zoo Wildl Med. 2012 Dec;43(4):828-35. doi: 10.1638/2011-0264R1.1.
7
Nasal mites (Acari:Halarachnidae) in the spotted seal, Phoca largha Pallas, and other pinnipeds of Alaskan waters.斑海豹（Phoca largha Pallas）及阿拉斯加海域其他鳍足类动物体内的鼻螨（蜱螨亚纲：海蛛螨科）
J Wildl Dis. 1982 Jan;18(1):63-8. doi: 10.7589/0090-3558-18.1.63.
8
Hair mercury concentrations in the spotted seal (Phoca largha) pups from the Sea of Japan.日本海斑海豹幼崽的毛发汞浓度。
Environ Sci Pollut Res Int. 2018 Sep;25(27):27133-27140. doi: 10.1007/s11356-018-2731-6. Epub 2018 Jul 18.
9
Genetic identification of novel poxviruses of cetaceans and pinnipeds.鲸类和鳍足类动物新型痘病毒的基因鉴定
Arch Virol. 2006 Mar;151(3):423-38. doi: 10.1007/s00705-005-0679-6. Epub 2005 Nov 21.
10
Breathing Air and Living Underwater: Molecular Evolution of Genes Related to Antioxidant Response in Cetaceans and Pinnipeds.呼吸空气和水下生活：鲸目动物和鳍足类动物抗氧化反应相关基因的分子进化。
J Mol Evol. 2024 Jun;92(3):300-316. doi: 10.1007/s00239-024-10170-3. Epub 2024 May 12.

引用本文的文献

1
Deep origins, distinct adaptations, and species-level status indicated for a glacial relict seal.一种冰川遗迹海豹的深层起源、独特适应性及物种水平地位得以揭示。
Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2503368122. doi: 10.1073/pnas.2503368122. Epub 2025 Jun 10.
2
Reference genome of the leopard seal (), a Southern Ocean apex predator.南极海狗（豹海豹）的参考基因组，一种南大洋顶级掠食者。
Front Genet. 2025 May 14;16:1561273. doi: 10.3389/fgene.2025.1561273. eCollection 2025.
3
Refinement of the Antarctic fur seal (Arctocephalus gazella) reference genome increases continuity and completeness.

本文引用的文献

1
The UCSC Genome Browser database: 2017 update.加州大学圣克鲁兹分校基因组浏览器数据库：2017年更新版
Nucleic Acids Res. 2017 Jan 4;45(D1):D626-D634. doi: 10.1093/nar/gkw1134. Epub 2016 Nov 29.
2
Hundreds of Genes Experienced Convergent Shifts in Selective Pressure in Marine Mammals.数百个基因在海洋哺乳动物的选择压力中经历了趋同变化。
Mol Biol Evol. 2016 Sep;33(9):2182-92. doi: 10.1093/molbev/msw112. Epub 2016 Jun 21.
3
Selection on different genes with equivalent functions: the convergence story told by Hox genes along the evolution of aquatic mammalian lineages.
南极软毛海豹（Arctocephalus gazella）参考基因组的精细化提高了连续性和完整性。
G3 (Bethesda). 2024 Nov 6;14(11). doi: 10.1093/g3journal/jkae179.
4
No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.在南极软毛海豹的杂种优势和亲缘关系的化学编码中，没有 MHC Ⅱ类基因型作用的证据。
Proc Biol Sci. 2024 Mar 27;291(2019):20232519. doi: 10.1098/rspb.2023.2519. Epub 2024 Mar 20.
5
Chromosome-Length Assembly of the Baikal Seal () Genome Reveals a Historically Large Population Prior to Isolation in Lake Baikal.贝加尔海豹基因组的染色体长度组装揭示了在贝加尔湖隔离之前的历史上较大的种群。
Genes (Basel). 2023 Feb 28;14(3):619. doi: 10.3390/genes14030619.
6
Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.濒危水生哺乳动物外胚层发育不良途径中的选择证据。
Integr Org Biol. 2022 Jul 19;4(1):obac018. doi: 10.1093/iob/obac018. eCollection 2022.
7
Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.高分辨率连接（Hi-C）构建的加利福尼亚海狮短读长读基因组组装结果在跨越 4500 万年进化的共线性推断方面具有广泛的一致性。
Mol Ecol Resour. 2021 Oct;21(7):2455-2470. doi: 10.1111/1755-0998.13443. Epub 2021 Jun 27.
对具有同等功能的不同基因的选择：水生哺乳动物谱系进化过程中Hox基因所讲述的趋同故事。
BMC Evol Biol. 2016 May 21;16(1):113. doi: 10.1186/s12862-016-0682-4.
4
A draft fur seal genome provides insights into factors affecting SNP validation and how to mitigate them.一份海狗基因组草图为影响单核苷酸多态性（SNP）验证的因素以及如何缓解这些因素提供了见解。
Mol Ecol Resour. 2016 Jul;16(4):909-21. doi: 10.1111/1755-0998.12502. Epub 2016 Jan 20.
5
Convergent evolution of marine mammals is associated with distinct substitutions in common genes.海洋哺乳动物的趋同进化与常见基因中的独特替换有关。
Sci Rep. 2015 Nov 9;5:16550. doi: 10.1038/srep16550.
6
BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.BUSCO：利用单拷贝同源基因评估基因组组装和注释的完整性。
Bioinformatics. 2015 Oct 1;31(19):3210-2. doi: 10.1093/bioinformatics/btv351. Epub 2015 Jun 9.
7
ScaffMatch: scaffolding algorithm based on maximum weight matching.ScaffMatch：基于最大权重匹配的支架算法。
Bioinformatics. 2015 Aug 15;31(16):2632-8. doi: 10.1093/bioinformatics/btv211. Epub 2015 Apr 17.
8
NxTrim: optimized trimming of Illumina mate pair reads.NxTrim：优化的 Illumina 配对读取修剪。
Bioinformatics. 2015 Jun 15;31(12):2035-7. doi: 10.1093/bioinformatics/btv057. Epub 2015 Feb 5.
9
Convergent evolution of the genomes of marine mammals.海洋哺乳动物基因组的趋同进化。
Nat Genet. 2015 Mar;47(3):272-5. doi: 10.1038/ng.3198. Epub 2015 Jan 26.
10
Comparative genomics reveals insights into avian genome evolution and adaptation.比较基因组学揭示了鸟类基因组进化和适应的见解。
Science. 2014 Dec 12;346(6215):1311-20. doi: 10.1126/science.1251385. Epub 2014 Dec 11.