利用新型基因组序列破译鳍足类动物的进化特征：Phoca largha、Callorhinus ursinus 和 Eumetopias jubatus 的首个基因组。
Deciphering the evolutionary signatures of pinnipeds using novel genome sequences: The first genomes of Phoca largha, Callorhinus ursinus, and Eumetopias jubatus.
机构信息
Biotechnology Research Division, National Institute of Fisheries Science, 216 Haean-ro, Gijang-eup, Gijang gun, Busan, 46083, Republic of Korea.
Interdisciplinary Program in Bioinformatics, Seoul National University, Kwan-ak Gu, Seoul, Republic of Korea.
出版信息
Sci Rep. 2018 Nov 15;8(1):16877. doi: 10.1038/s41598-018-34758-0.
The pinnipeds, which comprise seals, sea lions, and walruses, are a remarkable group of marine animals with unique adaptations to semi-aquatic life. However, their genomes are poorly characterized. In this study, we sequenced and characterized the genomes of three pinnipeds (Phoca largha, Callorhinus ursinus, and Eumetopias jubatus), focusing on site-wise sequence changes. We detected rapidly evolving genes in pinniped lineages and substitutions unique to pinnipeds associated with amphibious sound perception. Phenotypic convergence-related sequence convergences are not common in marine mammals. For example, FASN, KCNA5, and IL17RA contain substitutions specific to pinnipeds, yet are potential candidates of phenotypic convergence (blubber, response to hypoxia, and immunity to pathogens) in all marine mammals. The outcomes of this study will provide insight into targets for future studies of convergent evolution or gene function.
鳍足类动物包括海豹、海狮和海象，是一群适应半水生生活的非凡海洋动物。然而，它们的基因组特征尚未得到充分的描述。在这项研究中，我们对三种鳍足类动物（斑海豹、髯海豹和港湾海豹）的基因组进行了测序和特征描述，重点关注了位点特异性序列变化。我们检测到了鳍足类谱系中快速进化的基因，以及与两栖声音感知相关的鳍足类特有的替代。表型趋同相关的序列趋同并不常见于海洋哺乳动物中。例如，FASN、KCNA5 和 IL17RA 包含鳍足类特有的替代，然而它们是所有海洋哺乳动物中表型趋同（脂肪、对缺氧的反应和对病原体的免疫）的潜在候选基因。这项研究的结果将为未来的趋同进化或基因功能研究提供有价值的信息。
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