Thomas Solly, Patel Bimal, Varghese Sunitha S, Backianathan Selvamani
Radiation Oncology, Christian Medical College, Vellore, IND.
Pathology, Christian Medical College Hospital, Vellore, IND.
Cureus. 2018 Sep 10;10(9):e3275. doi: 10.7759/cureus.3275.
Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. One year, eight months later, he had a recurrence of the condition with leptomeningeal spread and was managed with re-excision of the recurrent lesion. Although our patient was disease-free for 20 months after the initial surgery, he survived only approximately five months after the second surgery, which reflects the associated poor prognosis of the disease.
神经皮肤黑色素瘤是一种罕见的先天性综合征，与伴有脑膜黑色素沉着或黑色素瘤的先天性黑素细胞痣相关。该疾病具有侵袭性，极易发生软脑膜转移。我们报告一例神经皮肤黑色素瘤患者的病史，该患者接受了根治性切除，随后进行了低分割辅助放疗。一年零八个月后，他病情复发并出现软脑膜播散，接受了复发病变的再次切除。尽管我们的患者在初次手术后20个月无病生存，但第二次手术后仅存活了约五个月，这反映了该疾病相关的预后较差。
