神经皮肤黑色素细胞增多症相关恶性黑色素瘤伴腹膜播种。
Neurocutaneous melanocytosis-associated malignant melanoma presenting with peritoneal seeding.
机构信息
Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA.
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Pediatr Dermatol. 2021 Sep;38(5):1298-1301. doi: 10.1111/pde.14789. Epub 2021 Aug 31.
Abstract
Neurocutaneous melanocytosis (NCM) is characterized by melanocyte deposition in the leptomeninges and brain parenchyma, primarily occurring in children with large or giant congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi. Patients with NCM may develop hydrocephalus and increased intracranial pressure, which can be managed with ventriculoperitoneal (VP) shunting. We present the case of a 16-month-old girl who developed peritoneal carcinomatosis and malignant ascites following VP shunting for hydrocephalus secondary to NCM to increase awareness of this rare, but serious, complication of cerebrospinal fluid diversion.
摘要
神经皮肤黑色素细胞增多症（NCM）的特征是黑色素细胞在软脑膜和脑实质中的沉积，主要发生在有大或巨大先天性黑色素痣（LCMN）或多发性先天性黑色素痣的儿童中。NCM 患者可能会发生脑积水和颅内压增高，可通过脑室腹膜（VP）分流来治疗。我们报告了一例 16 个月大的女孩，她在因 NCM 导致的脑积水行 VP 分流术后出现腹膜癌转移和恶性腹水，以提高对这种罕见但严重的脑脊液分流并发症的认识。
相似文献
1
Neurocutaneous melanocytosis-associated malignant melanoma presenting with peritoneal seeding.神经皮肤黑色素细胞增多症相关恶性黑色素瘤伴腹膜播种。
Pediatr Dermatol. 2021 Sep;38(5):1298-1301. doi: 10.1111/pde.14789. Epub 2021 Aug 31.
2
Neurocutaneous melanosis presenting with hydrocephalus. Case report and review of the literature.伴有脑积水的神经皮肤黑素沉着症。病例报告及文献综述。
J Neurosurg. 2005 Jan;102(1 Suppl):96-100. doi: 10.3171/ped.2005.102.1.0096.
3
Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update.以脑积水和恶性转化为表现的神经皮肤黑素沉着症：基于病例的最新进展
Childs Nerv Syst. 2018 Aug;34(8):1471-1477. doi: 10.1007/s00381-018-3851-5. Epub 2018 Jun 12.
4
Neurocutaneous melanocytosis (melanosis).神经皮肤黑素增多症（黑素沉着症）。
Childs Nerv Syst. 2020 Oct;36(10):2571-2596. doi: 10.1007/s00381-020-04770-9. Epub 2020 Oct 13.
5
Number of satellite nevi as a correlate for neurocutaneous melanocytosis in patients with large congenital melanocytic nevi.卫星痣数量与巨大先天性黑素细胞痣患者神经皮肤黑素沉着症的相关性
Arch Dermatol. 2004 Feb;140(2):171-5. doi: 10.1001/archderm.140.2.171.
6
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.免疫抑制后神经皮肤黑素沉着症（NCM）的恶性转化
Pediatr Dermatol. 2019 Jul;36(4):497-500. doi: 10.1111/pde.13804. Epub 2019 Mar 13.
7
Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registry.大先天性黑素细胞痣患者的无症状神经皮肤黑素沉着症：一项基于互联网登记处病例的研究
J Am Acad Dermatol. 2005 Dec;53(6):959-65. doi: 10.1016/j.jaad.2005.07.046. Epub 2005 Oct 7.
8
Neurocutaneous melanosis.神经皮肤黑素沉着症
Handb Clin Neurol. 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X.
9
[Neurocutaneous melanosis and malignant melanoma].[神经皮肤黑素沉着症与恶性黑色素瘤]
Hautarzt. 2004 Oct;55(10):971-4. doi: 10.1007/s00105-004-0807-3.
10
Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis.巨大先天性黑素细胞痣与恶性黑色素瘤及神经皮肤黑素沉着症发生的风险
Pediatrics. 2000 Oct;106(4):736-41. doi: 10.1542/peds.106.4.736.
引用本文的文献
1
Leptomeningeal Disease: Current Approaches and Future Directions.柔脑膜疾病：当前方法与未来方向
Curr Neurol Neurosci Rep. 2025 Mar 18;25(1):25. doi: 10.1007/s11910-025-01412-y.
2
Proton craniospinal irradiation with bevacizumab and pembrolizumab for leptomeningeal disease: a case report.贝伐珠单抗联合帕博利珠单抗行质子颅脊髓放疗治疗脑膜疾病 1 例报告
CNS Oncol. 2023 Sep 1;12(3):CNS101. doi: 10.2217/cns-2023-0005. Epub 2023 Jul 25.
本文引用的文献
1
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.神经皮肤黑色素细胞增多症和软脑膜黑色素瘤。
J Pediatr Hematol Oncol. 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680.
2
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.纳武利尤单抗联合伊匹木单抗治疗晚期黑色素瘤的 5 年生存数据
N Engl J Med. 2019 Oct 17;381(16):1535-1546. doi: 10.1056/NEJMoa1910836. Epub 2019 Sep 28.
3
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients.阿替利珠单抗联合考比替尼和维莫非尼治疗 BRAF 突变型黑色素瘤患者。
Nat Med. 2019 Jun;25(6):929-935. doi: 10.1038/s41591-019-0474-7. Epub 2019 Jun 6.
4
Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.基因重要吗？先天性黑素细胞痣的基因型-表型和基因型-结局关联。
Br J Dermatol. 2020 Feb;182(2):434-443. doi: 10.1111/bjd.18106. Epub 2019 Aug 9.
5
Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis.脑脊液体分流术治疗脑膜癌病患者的临床疗效。
World J Surg Oncol. 2019 Mar 27;17(1):59. doi: 10.1186/s12957-019-1595-7.
6
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.免疫抑制后神经皮肤黑素沉着症（NCM）的恶性转化
Pediatr Dermatol. 2019 Jul;36(4):497-500. doi: 10.1111/pde.13804. Epub 2019 Mar 13.
7
Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.伴有累及幕上和幕下的软脑膜黑色素瘤的神经皮肤黑色素沉着症
Cureus. 2018 Sep 10;10(9):e3275. doi: 10.7759/cureus.3275.
8
New insights into neurocutaneous melanosis.神经皮肤黑素沉着症的新见解。
Pediatr Radiol. 2018 Nov;48(12):1786-1796. doi: 10.1007/s00247-018-4205-x. Epub 2018 Aug 3.
9
Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update.以脑积水和恶性转化为表现的神经皮肤黑素沉着症：基于病例的最新进展
Childs Nerv Syst. 2018 Aug;34(8):1471-1477. doi: 10.1007/s00381-018-3851-5. Epub 2018 Jun 12.
10
Electrographic Correlates of Plateau Waves in Patients With Leptomeningeal Metastases.柔脑膜转移患者中高原波的脑电图相关性
Neurohospitalist. 2016 Oct;6(4):161-166. doi: 10.1177/1941874416648194. Epub 2016 May 11.
Zotero 插件