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JAK 1/2 Blockade in MDA5 Gain-of-Function.

作者信息

McLellan Kirsty E, Martin Neil, Davidson Joyce E, Cordeiro Nuno, Oates Bridget D, Neven Bénédicte, Rice Gillian I, Crow Yanick J

机构信息

Paediatric Rheumatology, Royal Hospital for Children, 1345 Govan Road, Glasgow, G514TF, UK.

Rainbow House Child Development Centre, Ayrshire General Hospital, Kilwinning Road, Irvine, KA128SS, UK.

出版信息

J Clin Immunol. 2018 Nov;38(8):844-846. doi: 10.1007/s10875-018-0563-2. Epub 2018 Nov 15.

DOI:10.1007/s10875-018-0563-2
PMID:30443754
Abstract
摘要

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JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.巴瑞替尼治疗自身炎症性干扰素病的 JAK1/2 抑制作用。
J Clin Invest. 2018 Jul 2;128(7):3041-3052. doi: 10.1172/JCI98814. Epub 2018 Jun 11.
2
An open-label trial of JAK 1/2 blockade in progressive -associated neuroinflammation.一项关于JAK 1/2阻断剂在进行性相关神经炎症中的开放标签试验。
Neurology. 2018 Feb 6;90(6):289-291. doi: 10.1212/WNL.0000000000004921. Epub 2018 Jan 10.
3
Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview.
JAK抑制在Aicardi-Goutières综合征中的应用：一项单中心多学科真实世界研究
J Clin Immunol. 2023 Aug;43(6):1436-1447. doi: 10.1007/s10875-023-01500-z. Epub 2023 May 12.
4
Breaking down the cellular responses to type I interferon neurotoxicity in the brain.解析 I 型干扰素诱导的脑神经元毒性的细胞反应。
Front Immunol. 2023 Feb 3;14:1110593. doi: 10.3389/fimmu.2023.1110593. eCollection 2023.
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Case Report: Generalised Panniculitis as a Post-COVID-19 Presentation in Aicardi-Goutières Syndrome Treated With Ruxolitinib.病例报告：芦可替尼治疗的Aicardi-Goutières综合征中，新冠病毒感染后出现的全身性脂膜炎
Front Pediatr. 2022 Apr 25;10:837568. doi: 10.3389/fped.2022.837568. eCollection 2022.
6
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes.DNA 损伤导致 Aicardi-Goutières 综合征星形胶质细胞的神经毒性炎症。
J Exp Med. 2022 Apr 4;219(4). doi: 10.1084/jem.20211121. Epub 2022 Mar 9.
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Front Pediatr. 2022 Feb 8;10:820586. doi: 10.3389/fped.2022.820586. eCollection 2022.
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Lancet Neurol. 2013 Dec;12(12):1159-69. doi: 10.1016/S1474-4422(13)70258-8. Epub 2013 Oct 30.
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Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis.在骨髓纤维化患者停止使用芦可替尼治疗期间的严重不良事件。
Mayo Clin Proc. 2011 Dec;86(12):1188-91. doi: 10.4065/mcp.2011.0518. Epub 2011 Oct 27.