Halikowski M J, Liew C C
Department of Clinical Biochemistry, Banting Institute, University of Toronto, Ont., Canada.
Biochem Cell Biol. 1988 May;66(5):349-66. doi: 10.1139/o88-043.
Many nonhistone nuclear proteins have been shown to be phosphorylated and associated with a diverse range of cellular activities. The aim of this present review is to update the most recent developments in this field with respect to the traditional roles that these proteins have been postulated to play as enzymes, DNA-binding proteins, hormonal receptors, nucleosome associated proteins, and nucleolar associated proteins. In addition, evidence is presented suggesting that these proteins may also function as nuclear oncogene protein products, structural constituents of nuclear organization (e.g., lamina-nuclear matrix associated proteins), and RNA processing factors.
许多非组蛋白核蛋白已被证明会发生磷酸化，并与多种细胞活动相关。本综述的目的是就这些蛋白作为酶、DNA结合蛋白、激素受体、核小体相关蛋白和核仁相关蛋白所假定发挥的传统作用，更新该领域的最新进展。此外，有证据表明这些蛋白还可能作为核癌基因蛋白产物、核组织的结构成分（如核纤层-核基质相关蛋白）以及RNA加工因子发挥作用。
