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多发性肌炎和皮肌炎患者的角膜受累。

Corneal Involvement of Patients with Polymyositis and Dermatomyositis.

机构信息

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

出版信息

Ocul Immunol Inflamm. 2020;28(1):58-66. doi: 10.1080/09273948.2018.1547407. Epub 2018 Nov 16.

Abstract

: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls.: A total of 43 PM and 32 DM patients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Objective clinical tests of dry eye disease (DED) were also performed.: All pachymetric measurements and corneal volumes (CVs) proved to be significantly lower both in PM and DM patients. The values of DM patients were closer to control values than those of the PM patients. For tear break-up time and Schirmer-I test values significant differences were observed between patients and controls, with values decreased both in PM and DM patients.: PM patients rather than DM patients tend to develop thinner and low-volume corneas as compared to controls. Additionally, a high prevalence of DED among both PM and DM patients was also detected.

摘要

目的

评估多发性肌炎(PM)和皮肌炎(DM)患者的角膜参数,并与健康对照组进行比较。

方法

本研究为一项横断面、观察性、病例对照研究,共纳入 43 例 PM 患者、32 例 DM 患者和 93 例健康对照者。采用 Pentacam 评估角膜参数。还进行了干眼症(DED)的客观临床检查。

结果

PM 和 DM 患者的所有角膜厚度和角膜容积(CV)测量值均显著降低。DM 患者的数值比 PM 患者更接近对照组。在泪膜破裂时间和 Schirmer-I 试验值方面,患者与对照组之间存在显著差异,PM 和 DM 患者的这些值均降低。

结论

与对照组相比,PM 患者而非 DM 患者的角膜更薄,体积更小。此外,还发现 PM 和 DM 患者中 DED 的患病率较高。

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