Memeo Antonio, Verdoni Fabio, Ingraffia Caterina, Rossi Laura, Pedretti Leopoldo, D'Amato Raffaele D, Peretto Laura, Mineo Giuseppe V
Department of Pediatric Orthopaedics and Traumatology.
Department of Pediatric Orthopaedics and Traumatology, IRCCS 'Galeazzi' Orthopedic Institute, Milan, Italy.
J Pediatr Orthop B. 2019 May;28(3):221-227. doi: 10.1097/BPB.0000000000000571.
Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.
分期肢体延长术可使软骨发育不全性侏儒达到接近正常的身高，但需要长时间的外固定，且可能出现骨愈合延迟的问题。2009年至2013年期间，我院有8例软骨发育不全性侏儒在股骨延长阶段的骨痂形成过程中出现骨愈合延迟。我们对其进行了骨髓源性干细胞浓缩物的原位注射。患者每月接受临床和影像学评估以确定愈合率。所有8例患者再生骨均有改善，平均愈合指数为23.1天/厘米（范围：18.7 - 23.8天/厘米）。延迟骨愈合的完全恢复平均需要5.2个月（范围：2 - 10个月）。在这些患者中使用细胞疗法可能代表一种创新应用。
