Department of Physiology, Fukuoka University School of medicine, Nanakuma 7-451, Jonan-ku, Fukuoka 814-0180, Japan.
Department of Physiology, Fukuoka University School of medicine, Nanakuma 7-451, Jonan-ku, Fukuoka 814-0180, Japan.
Semin Cell Dev Biol. 2019 Oct;94:40-49. doi: 10.1016/j.semcdb.2018.11.002. Epub 2018 Nov 17.
It is now widely accepted that advanced fibrosis underlies many chronic inflammatory disorders and is the main cause of morbidity and mortality of the modern world. The pathogenic mechanism of advanced fibrosis involves diverse and intricate interplays between numerous extracellular and intracellular signaling molecules, among which the non-trivial roles of a stress-responsive Ca/Na-permeable cation channel superfamily, the transient receptor potential (TRP) protein, are receiving growing attention. Available evidence suggests that several TRP channels such as TRPC3, TRPC6, TRPV1, TRPV3, TRPV4, TRPA1, TRPM6 and TRPM7 may play central roles in the progression and/or prevention of fibroproliferative disorders in vital visceral organs such as lung, heart, liver, kidney, and bowel as well as brain, blood vessels and skin, and may contribute to both acute and chronic inflammatory processes involved therein. This short paper overviews the current knowledge accumulated in this rapidly growing field, with particular focus on cardiac and intestinal fibrosis, which are tightly associated with the pathogenesis of atrial fibrillation and inflammatory bowel diseases such as Crohn's disease.
现在人们普遍认为，晚期纤维化是许多慢性炎症性疾病的基础，也是现代世界发病率和死亡率的主要原因。晚期纤维化的发病机制涉及多种细胞外和细胞内信号分子之间复杂的相互作用，其中应激反应性 Ca/Na 通透性阳离子通道超家族（瞬时受体电位（TRP）蛋白）的重要作用正受到越来越多的关注。现有证据表明，几种 TRP 通道，如 TRPC3、TRPC6、TRPV1、TRPV3、TRPV4、TRPA1、TRPM6 和 TRPM7，可能在肺、心脏、肝脏、肾脏、肠道等重要内脏器官以及脑、血管和皮肤中的纤维增生性疾病的进展和/或预防中发挥核心作用，并可能参与其中涉及的急性和慢性炎症过程。本文综述了这一快速发展领域的最新知识，特别关注与心房颤动和炎症性肠病（如克罗恩病）发病机制密切相关的心脏和肠道纤维化。
