糖基控制病毒感染：第一届国际糖病毒学研讨会报告德国绍恩塔尔，2018 年 5 月 2 日至 4 日。

Glycans Controlling Virus Infections: Meeting Report on the 1st International Symposium on Glycovirology Schöntal, Germany, 02⁻04 May 2018.

机构信息

Interfaculty Institute of Biochemistry, University of Tübingen, D-72706 Tübingen, Germany.

Research Group "ViroCarb: Glycans controlling non-enveloped virus infections", Coordinating University of Tübingen, D-72706 Tübingen, Germany.

出版信息

Viruses. 2018 Nov 15;10(11):636. doi: 10.3390/v10110636.

DOI:10.3390/v10110636

PMID:30445709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6266297/

Abstract

Glycans are, with nucleic acids, proteins and lipids, one of the four founding structures of cellular life. Due to their non-template synthesis, they are inherently heterogeneous and difficult to study with regards to their structure and function. Since 2016, the research group ViroCarb, funded by the German Research Foundation, has investigated the role of glycans in non-enveloped virus infections with a highly interdisciplinary approach. The core idea was to bring together scientists and students from various disciplines such as structural biology, cell biology, virology and chemistry to advance research by an interdisciplinary means. In 2018, ViroCarb hosted the 1st International Symposium on Glycovirology in Schöntal, Germany, with a similar aim. Scientists from various disciplines gathered to discuss their area of study, present recent findings, establish or strengthen collaborations, and mentor the next generation of glycovirologists through formal presentations and informal discussions. The secluded meeting at the monastery of Schöntal gave ample time for in-depth discussions. On behalf of ViroCarb, this report summarizes the reports and highlights advances in the field.

摘要

糖胺聚糖与核酸、蛋白质和脂类一起，是细胞生命的四大基础结构之一。由于其非模板合成，它们在结构和功能方面具有固有异质性，难以研究。自 2016 年以来，由德国研究基金会资助的 ViroCarb 研究小组采用高度跨学科的方法研究了聚糖在非包膜病毒感染中的作用。核心思想是汇集来自结构生物学、细胞生物学、病毒学和化学等不同学科的科学家和学生，通过跨学科手段推进研究。2018 年，ViroCarb 在德国 Schöntal 举办了第一届国际糖病毒学研讨会，目标类似。来自不同学科的科学家聚集在一起讨论他们的研究领域，展示最新发现，建立或加强合作，并通过正式报告和非正式讨论指导下一代糖病毒学家。在 Schöntal 修道院举行的封闭式会议为深入讨论提供了充足的时间。本文代表 ViroCarb 总结了报告内容，并重点介绍了该领域的进展。