College of Life Science and Bio-engineering, Beijing University of Technology, Beijing, China.
Beijing Institute of Radiation Medicine, Beijing, China.
Nat Prod Res. 2020 Mar;34(6):847-850. doi: 10.1080/14786419.2018.1501692. Epub 2018 Nov 16.
Thirty-three compounds (-) were isolated from the rhizomes of . Their structures were elucidated on the basis of spectral analysis and identified as -kaurene terpenoids (1-3), anthraquinones (4-8), flavonoids (9-12), steroids (13-15), and other compounds (-). Compound -, - were isolated from the genus osmunda for the first time. Compound were isolated from the plant for the first time. Cytotoxicities of all compounds against Hela, HepG2 and A549 cell lines were measured by MTT assay, and their antioxidant activities were determined by DPPH and ABTS radical scavenging assays. Compound exhibited potent cytotoxicity against Hela, HepG2 cell lines with IC values of 9.31 and 9.66 μM, respectively. Compound showed good antioxidant activity. The Trolox-equivalent antioxidant capacity (TEAC) value was 0.95 mM in ABTS assay, and the IC value was 18.63 μM in DPPH assay.
从凤尾蕨科植物根茎中分离得到 33 种化合物(-)。根据光谱分析鉴定了它们的结构，这些化合物被鉴定为贝壳杉烯萜类化合物（1-3）、蒽醌类化合物（4-8）、黄酮类化合物（9-12）、甾体类化合物（13-15）和其他化合物（-）。化合物-、-首次从凤尾蕨属植物中分离得到。化合物-首次从该植物中分离得到。采用 MTT 法测定了所有化合物对 Hela、HepG2 和 A549 细胞系的细胞毒性，并采用 DPPH 和 ABTS 自由基清除试验测定了它们的抗氧化活性。化合物-对 Hela、HepG2 细胞系表现出较强的细胞毒性，IC 值分别为 9.31 和 9.66 μM。化合物-显示出良好的抗氧化活性。在 ABTS 试验中，Trolox 当量抗氧化能力（TEAC）值为 0.95 mM，在 DPPH 试验中，IC 值为 18.63 μM。
