Cellular Neurobiology Laboratory CNB-S, Salk Institute, La Jolla, CA 92037-1002, USA.
BioScience Center (BSC), San Diego State University, San Diego, CA 92105, USA.
Trends Pharmacol Sci. 2018 Dec;39(12):1004-1007. doi: 10.1016/j.tips.2018.09.008. Epub 2018 Nov 13.
Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.
衰老抑制剂是能够减缓生物衰老速度的化合物,因此可能会降低与年龄相关的疾病(如阿尔茨海默病,AD)的发病率。然而,在哺乳动物 AD 模型中,很少有治疗效果的衰老抑制剂。在这里,我们描述了神经保护衰老抑制剂(GNPs)的鉴定,这是一种新型 AD 候选药物,符合衰老抑制剂的标准。