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Geroscience and Alzheimer's Disease Drug Development.
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The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.
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Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors.
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Deep Modeling of Regulating Effects of Small Molecules on Longevity-Associated Genes.
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extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3.
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Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer's Disease.
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The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12715. Epub 2018 Jan 7.
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A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism.
Alzheimers Res Ther. 2017 Jul 14;9(1):50. doi: 10.1186/s13195-017-0277-3.
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Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.
J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):299-307. doi: 10.1093/gerona/glx104.
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Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery.
Alzheimers Dement. 2016 Jun;12(6):678-86. doi: 10.1016/j.jalz.2016.03.016. Epub 2016 May 2.
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Calorie restriction as an intervention in ageing.
J Physiol. 2016 Apr 15;594(8):2043-60. doi: 10.1113/JP270543. Epub 2016 Jan 3.
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A comprehensive multiomics approach toward understanding the relationship between aging and dementia.
Aging (Albany NY). 2015 Nov;7(11):937-55. doi: 10.18632/aging.100838.
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Clinical development of curcumin in neurodegenerative disease.
Expert Rev Neurother. 2015 Jun;15(6):629-37. doi: 10.1586/14737175.2015.1044981.
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How fisetin reduces the impact of age and disease on CNS function.
Front Biosci (Schol Ed). 2015 Jun 1;7(1):58-82. doi: 10.2741/S425.
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Back to the future with phenotypic screening.
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