Swaak A J, Visch L L, Zonneveld A
Dr Daniel den Hoed Clinic, Department of Rheumatology, Rotterdam, The Netherlands.
Clin Rheumatol. 1988 Mar;7(1):28-34. doi: 10.1007/BF02284053.
To evaluate the diagnostic significance of salivary beta 2m in Sjögren's syndrome we measured salivary beta 2m levels in 19 patients with primary sicca syndrome (PSS), 15 with secondary Sjögren's syndrome (SSS) and compared the results with 20 normal healthy persons. We showed that beta 2m is specifically excreted in the saliva, because in normal saliva the concentration of beta 2m was unrelated to IgA levels. Also in normals, there was no relationship between serum and saliva concentrations of beta 2m. The mean saliva levels of beta 2m were increased in PSS (1.13 +/- 0.58) and SSS (1.39 +/- 0.69) compared with the levels in normals (0.53 +/- 0.22). The determination of beta 2m in the saliva can therefore be used as a noninvasive measurement for the confirmation of the diagnosis Sjögren's syndrome.
为评估唾液β2微球蛋白在干燥综合征中的诊断意义，我们检测了19例原发性干燥综合征（PSS）患者、15例继发性干燥综合征（SSS）患者的唾液β2微球蛋白水平，并将结果与20名正常健康人进行比较。我们发现β2微球蛋白在唾液中特异性排出，因为在正常唾液中，β2微球蛋白浓度与IgA水平无关。同样在正常人中，血清和唾液中β2微球蛋白浓度之间也没有关系。与正常人（0.53±0.22）相比，PSS患者（1.13±0.58）和SSS患者（1.39±0.69）的唾液β2微球蛋白平均水平升高。因此，唾液中β2微球蛋白的测定可作为一种无创检测方法用于确诊干燥综合征。
