Oosawa Fumio
Department of Physics, Graduate School of Science, Nagoya University, Nagoya, 464-8602, Japan.
Institute of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Aichi, 464-8602, Japan.
Biophys Rev. 2018 Dec;10(6):1481-1482. doi: 10.1007/s12551-018-0485-5. Epub 2018 Nov 16.
In this short review, I describe a brief history of the discovery of myosin I isolated from Acanthamoeba in 1973 by Tom Pollard and Ed Korn. Today, myosins form a large "family tree" that includes more than 30 types of myosins. I discuss the importance of the relationship among actin, myosin, and other actin-binding proteins, many of which were pioneered by Pollard-san ("-san" is a Japanese honorific suffix showing respect, politeness and friendship). At the first conference devoted to actin, Pollard-san, Korn-san, and I discussed the importance of the nucleotide bound at the two ends of the actin filament. I conclude that life is a dynamic accumulation of molecule-molecule bindings, and although we do not yet know how they coordinate with each other to operate a living cell, many enthusiastic and excellent researchers like Pollard-san will unveil mechanisms that will show us what life really looks like.
在这篇简短的综述中，我讲述了1973年汤姆·波拉德（Tom Pollard）和埃德·科恩（Ed Korn）从棘阿米巴中分离出肌球蛋白I的发现简史。如今，肌球蛋白构成了一个庞大的“家族树”，其中包括30多种肌球蛋白。我讨论了肌动蛋白、肌球蛋白和其他肌动蛋白结合蛋白之间关系的重要性，其中许多研究是由波拉德先生（“先生”是日语中的敬称后缀，表达尊重、礼貌和友好）开创的。在首届关于肌动蛋白的会议上，波拉德先生、科恩先生和我讨论了结合在肌动蛋白丝两端的核苷酸的重要性。我得出结论，生命是分子与分子结合的动态积累，尽管我们尚不知道它们如何相互协调以运作活细胞，但像波拉德先生这样许多热情且优秀的研究人员将揭示其机制，向我们展示生命的真实面貌。
