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在体伏安证据表明，蓝斑核的激活主要在边缘下皮质释放去甲肾上腺素：急性乙醇的影响。

In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol.

机构信息

Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

出版信息

Synapse. 2019 Apr;73(4):e22080. doi: 10.1002/syn.22080. Epub 2018 Nov 22.

DOI:10.1002/syn.22080
PMID:30447016
Abstract

Using fast-scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and not affected by acute ethanol. With previous work, these data suggest differential effects of ethanol on prefrontal norepinephrine and dopamine, a region important in addiction-related pathways.

摘要

采用快速扫描循环伏安法结合药理学，作者表明蓝斑刺激后前额叶皮质儿茶酚胺的释放是去甲肾上腺素能的，而不是多巴胺能的，并且不受急性乙醇的影响。结合之前的工作，这些数据表明乙醇对与成瘾相关途径有关的前额叶皮质去甲肾上腺素和多巴胺有不同的影响。

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本文引用的文献

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Noradrenergic Modulation of Dopamine Transmission Evoked by Electrical Stimulation of the Locus Coeruleus in the Rat Brain.去甲肾上腺素对大鼠蓝斑刺激诱发的多巴胺传递的调制。
ACS Chem Neurosci. 2017 Sep 20;8(9):1913-1924. doi: 10.1021/acschemneuro.7b00078. Epub 2017 Jun 21.
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Differentiating Siblings: The Case of Dopamine and Norepinephrine.区分兄弟姐妹：多巴胺和去甲肾上腺素的案例。
ACS Chem Neurosci. 2017 Feb 15;8(2):218-220. doi: 10.1021/acschemneuro.7b00056. Epub 2017 Feb 8.
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Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.
在两个为达到高血液乙醇浓度而选择的近交系重复小鼠品系中，急性乙醇诱导的C-Fos激活的不同和重叠模式。
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Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release.乙醇通过抑制去甲肾上腺素释放来消除小鼠警觉依赖的星形胶质细胞网络激活。
Nat Commun. 2020 Dec 2;11(1):6157. doi: 10.1038/s41467-020-19475-5.
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Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation.蓝斑光激活双向控制饮酒行为。
Neuroscience. 2020 Sep 1;443:84-92. doi: 10.1016/j.neuroscience.2020.07.024. Epub 2020 Jul 21.
甘丙肽会导致单胺能功能障碍以及癫痫相关的神经行为共病。
Exp Neurol. 2017 Mar;289:64-72. doi: 10.1016/j.expneurol.2016.12.008. Epub 2016 Dec 22.
4
Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis.延髓去甲肾上腺素投射将去甲肾上腺素释放到终纹床核的对侧。
ACS Chem Neurosci. 2016 Dec 21;7(12):1681-1689. doi: 10.1021/acschemneuro.6b00210. Epub 2016 Sep 27.
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Alcohol Clin Exp Res. 2014 Dec;38(12):2969-77. doi: 10.1111/acer.12587.
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Acute ethanol inhibits dopamine release in the nucleus accumbens via α6 nicotinic acetylcholine receptors.急性乙醇通过α6 烟碱型乙酰胆碱受体抑制伏隔核多巴胺释放。
J Pharmacol Exp Ther. 2014 Jun;349(3):559-67. doi: 10.1124/jpet.113.211490. Epub 2014 Mar 18.