Dickinson A G, Outram G W
AFRC & MRC Neuropathogenesis Unit, Edinburgh, UK.
Ciba Found Symp. 1988;135:63-83. doi: 10.1002/9780470513613.ch5.
The properties of genes involved directly or indirectly in the pathogenesis of scrapie and other unconventional (UCV) virus infections are reviewed. Reasons are presented for assigning paramount importance to the Sinc gene in mice and the Sip gene in sheep (the likely homologue of Sinc). The rationale is given for concluding that the agents of UCV infections have their own genomic molecules coding for strain differences. The virino hypothesis, which proposes that the infective form of the agent is an informational hybrid between the agent's genome and protective host proteins, is presented in detail, with an explanation of the postulated role of Sinc.
本文综述了直接或间接参与羊瘙痒病及其他非传统病毒（UCV）感染发病机制的基因特性。阐述了将小鼠中的Sinc基因和绵羊中的Sip基因（可能是Sinc的同源物）视为至关重要的原因。给出了得出UCV感染病原体具有编码毒株差异的自身基因组分子这一结论的理论依据。详细介绍了病毒蛋白侵染颗粒假说，该假说认为病原体的感染形式是病原体基因组与保护性宿主蛋白之间的信息杂种，并对Sinc假定的作用进行了解释。
