State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.
Chembiochem. 2019 Mar 1;20(5):667-671. doi: 10.1002/cbic.201800648. Epub 2019 Jan 23.
Manipulating the cross-coupling of gold nanoparticles (AuNPs) to maximize the photothermal effect is a promising strategy for cancer therapy. Here, by taking advantage of the well-known tetrazole/alkene photoclick chemistry, we have demonstrated for the first time that small AuNPs (23 nm) decorated with both 2,5-diphenyltetrazole and methacrylic acid on their surfaces can form covalently crosslinked aggregates upon laser irradiation (λ=405 nm). In vitro studies indicated that the light-triggered assembling shifted the surface plasmon resonance of AuNPs significantly to near-infrared (NIR) regions, which as a consequence effectively enhanced the efficacy of photothermal therapy for 4T1 breast cancer cells. We thus believe that this new light-triggered cross-coupling approach might offer a valuable tool for cancer treatment.
操纵金纳米粒子（AuNPs）的交叉偶联以最大限度地发挥光热效应是癌症治疗的一种很有前途的策略。在这里，我们利用众所周知的四唑/烯烃光点击化学，首次证明了表面同时修饰有 2,5-二苯基四唑和甲基丙烯酸的小 AuNPs（23nm）在激光照射（λ=405nm）下可以形成共价交联的聚集体。体外研究表明，光引发的组装显著将 AuNPs 的表面等离子体共振转移到近红外（NIR）区域，从而有效地增强了对 4T1 乳腺癌细胞的光热治疗效果。因此，我们相信这种新的光触发交叉偶联方法可能为癌症治疗提供一种有价值的工具。
