Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan 410011, China.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan 410011, China.
Brain Res. 2019 Mar 15;1707:1-7. doi: 10.1016/j.brainres.2018.11.020. Epub 2018 Nov 14.
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders. The current study explored the effect of rs110402 genotype on psychological stress processing in healthy adults.
The Montreal Imaging Stress Task (MIST) was administered to 140 healthy adults (34 C carriers and 106 TT homozygotes) during functional magnetic resonance imaging. Between-group differences in self-reported stress level, whole brain activation, and cortisol levels were assessed.
The rs110402 genotype groups differed in stress-induced cortisol response and bilateral dorsal anterior cingulate cortex (dACC) activity. The TT homozygotes showed greater stress-induced activation in the bilateral dACC compared to C carriers. Interestingly, dACC activity during MIST was negatively correlated with cortisol response in healthy adults. State anxiety, trait anxiety, and mental resilience did not differ between genotypes.
CRHR1 SNP rs110402 genotype plays a role in psychosocial neural processing and cortisol response in healthy adults. The activity in dACC may mediate effect of rs110402 on psychosocial stress processing in the healthy population. Moreover, level of dACC activation may be associated with stress vulnerability.
有人提出，常见的内含子 CRHR1 SNP rs110402 与焦虑和皮质醇反应模式有关，并在易患某些精神障碍方面发挥关键作用。本研究探讨了 rs110402 基因型对健康成年人心理应激处理的影响。
在功能磁共振成像期间，对 140 名健康成年人（34 名 C 携带者和 106 名 TT 纯合子）进行了蒙特利尔成像应激任务（MIST）。评估了报告的应激水平、全脑激活和皮质醇水平的组间差异。
rs110402 基因型组在应激诱导的皮质醇反应和双侧背侧前扣带皮层（dACC）活性方面存在差异。与 C 携带者相比，TT 纯合子在双侧 dACC 中显示出更大的应激诱导激活。有趣的是，MIST 期间的 dACC 活性与健康成年人的皮质醇反应呈负相关。状态焦虑、特质焦虑和心理弹性在基因型之间没有差异。
CRHR1 SNP rs110402 基因型在健康成年人的心理社会神经处理和皮质醇反应中起作用。dACC 的活动可能介导 rs110402 对健康人群心理社会应激处理的影响。此外，dACC 激活水平可能与应激易感性有关。
