Sun Xiaoqiang, Ming Qingsen, Zhong Xue, Dong Daifeng, Li Chuting, Xiong Ge, Cheng Chang, Cao Wanyi, He Jiayue, Wang Xiang, Yi Jinyao, Yao Shuqiao
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Medical Psychological Institute of Central South University, Changsha, China.
Front Behav Neurosci. 2020 May 15;14:65. doi: 10.3389/fnbeh.2020.00065. eCollection 2020.
The stress response is regulated by many mechanisms. Monoamine oxidase A (MAOA) has been related to many mental illnesses. However, few studies have explored the relationship between MAOA and acute laboratory-induced psychosocial stress with functional magnetic resonance imaging (fMRI). In the current study, the Montreal Imaging Stress Task (MIST) and fMRI were used to investigate how MAOA influences the stress response. Increased cortisol concentrations were observed after the task; functional connectivity between the bilateral anterior hippocampus and other brain regions was reduced during stress. MAOA-H allele carriers showed greater deactivation of the right anterior hippocampus and greater cortisol response after stress than did MAOH-L allele carriers. Hippocampal deactivation may lead to disinhibition of the hypothalamic-pituitary-adrenal (HPA) axis and the initiation of stress hormone release under stress. Our results suggest that the MAOA gene regulates the stress response by influencing the right anterior hippocampus.
应激反应受多种机制调控。单胺氧化酶A（MAOA）与多种精神疾病有关。然而，很少有研究利用功能磁共振成像（fMRI）探究MAOA与急性实验室诱发的心理社会应激之间的关系。在本研究中，采用蒙特利尔成像应激任务（MIST）和fMRI来研究MAOA如何影响应激反应。任务后观察到皮质醇浓度升高；应激期间双侧前海马与其他脑区之间的功能连接减少。与MAO-H低等位基因携带者相比，MAO-H高等位基因携带者在应激后右侧前海马的失活程度更高，皮质醇反应也更强。海马失活可能导致下丘脑-垂体-肾上腺（HPA）轴的去抑制，并在应激状态下引发应激激素释放。我们的结果表明，MAOA基因通过影响右侧前海马调节应激反应。
