人心力衰竭中的心肌舒张：为什么肌节动力学应该成为焦点。
Myocardial relaxation in human heart failure: Why sarcomere kinetics should be center-stage.
机构信息
Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, USA.
出版信息
Arch Biochem Biophys. 2019 Jan;661:145-148. doi: 10.1016/j.abb.2018.11.011. Epub 2018 Nov 14.
Abstract
Myocardial relaxation is critical for the heart to allow for adequate filling of the ventricles prior to the next contraction. In human heart failure, impairment of myocardial relaxation is a major problem, and impacts most patients suffering from end-stage failure. Furthering our understanding of myocardial relaxation is critical in developing future treatment strategies. This review highlights processes involved in myocardial relaxation, as well as governing processes that modulate myocardial relaxation, with a focus on impairment of myocardium-level relaxation in human end-stage heart failure.
摘要
心肌弛豫对于心脏在下次收缩前充分充盈心室至关重要。在人类心力衰竭中，心肌弛豫受损是一个主要问题，影响大多数终末期心力衰竭患者。深入了解心肌弛豫对于制定未来的治疗策略至关重要。本综述重点介绍了心肌弛豫涉及的过程以及调节心肌弛豫的控制过程，特别关注人类终末期心力衰竭中心脏肌水平弛豫的受损情况。
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