Rotman Lauren E, Vaughan T Brooks, Hackney James R, Riley Kristen O
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Endocrinology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
World Neurosurg. 2019 Feb;122:417-423. doi: 10.1016/j.wneu.2018.11.011. Epub 2018 Nov 14.
Pituitary carcinomas are rare and aggressive neoplasms that despite current treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone pituitary tumors have been shown to alter their clinical manifestations with conversion to Cushing disease and silent types.
The purpose of this paper is to present the first documented case of an adrenocorticotrophic hormone-secreting pituitary adenoma with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with metastases to distant sites in the central nervous system.
This patient was later treated with radiotherapy, temozolomide, and bevacizumab, with 8 years of progression-free survival.
垂体癌是罕见的侵袭性肿瘤，尽管有当前的治疗方案，但其预后仍然很差。促肾上腺皮质激素垂体瘤已被证明会随着转变为库欣病和沉默型而改变其临床表现。
本文的目的是介绍首例有记录的分泌促肾上腺皮质激素的垂体腺瘤伴库欣病，该腺瘤分化为沉默型促肾上腺皮质激素垂体癌并转移至中枢神经系统的远处部位。
该患者后来接受了放疗、替莫唑胺和贝伐单抗治疗，无进展生存期达8年。
