Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Mol Cancer. 2018 Nov 17;17(1):158. doi: 10.1186/s12943-018-0900-3.
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.
炎症小体是一种大型的细胞内多蛋白信号复合物，作为对细胞溶质中内源性危险信号的炎症免疫反应而形成。炎症小体的形成使炎性蛋白酶半胱天冬酶-1（caspase-1）的激活、随后促炎细胞因子白细胞介素（IL）-1β和 proIL-18 的 活性形式的切割的细胞焦亡起始成为可能。炎症小体复合物由 Nod 样受体（NLR）、衔接凋亡相关斑点样蛋白（ASC）和 Caspase-1 组成。NLRP3 炎症小体激活的失调与肿瘤发病机制有关，尽管由于描述的结果不一致，其在癌症发展和进展中的作用仍存在争议。在这篇综述中，我们总结了 NLRP3 炎症小体在潜在癌症促进和治疗中的作用的最新知识。
