Department of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Department of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China,
Eur Neurol. 2020;83(6):576-580. doi: 10.1159/000509798. Epub 2020 Nov 17.
Inflammasomes are large intracellular multi-protein signaling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1 and pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a nod-like receptor, the adapter apoptosis-associated speck-like protein, and caspase-1. Dysregulation of NLRP3 inflammasome activation is involved in neuroinflammation disease pathogenesis, although its role in SCI development and progression remains controversial due to the inconsistent findings described.
In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential neuroinflammation diseases therapy.
炎症小体是一种大型的细胞内多蛋白信号复合物，在细胞质中形成，作为对内源性危险信号的炎症免疫反应。炎症小体的形成使炎性蛋白酶半胱氨酸蛋白酶-1（caspase-1）激活，并引发细胞焦亡，随后将促炎细胞因子白细胞介素（IL）-1β和前白细胞介素（proIL）-18 切割成活性形式。炎症小体复合物由 NOD 样受体、衔接凋亡相关斑点样蛋白和半胱氨酸蛋白酶-1（caspase-1）组成。NLRP3 炎症小体激活的失调与神经炎症疾病的发病机制有关，尽管由于描述的结果不一致，其在 SCI 发展和进展中的作用仍存在争议。
在这篇综述中，我们总结了 NLRP3 炎症小体在潜在的神经炎症疾病治疗中的作用的最新知识。
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