Puchalski Mary L, Russell Terri L, Karlsen Kristine A
Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Neonatology, 25 East Chicago Avenue, Chicago, IL 60611, USA; Department of Women, Children, and Family Health Science, University of Illinois at Chicago, 845 South Damen Avenue, M/C 802, Chicago, IL 60612, USA.
Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Neonatology, 25 East Chicago Avenue, Chicago, IL 60611, USA; Department of Women, Children, and Family Health Science, University of Illinois at Chicago, 845 South Damen Avenue, M/C 802, Chicago, IL 60612, USA.
Crit Care Nurs Clin North Am. 2018 Dec;30(4):467-480. doi: 10.1016/j.cnc.2018.07.004.
Hypoglycemia is one of the most common neonatal problems. Despite increasing evidence that hypoglycemia is linked to neurologic impairment, knowledge regarding the specific value or duration of hypoglycemia that results in injury to the brain remains unclear. Current published statements/guidelines focused on preventing clinically significant hypoglycemia are conflicting and continue to be based on low evidence. This article reviews transitional events leading to extrauterine euglycemia, risk factors contributing to transient or persistent hypoglycemia, and common treatment approaches. Current information related to neurodevelopmental outcomes and screening strategies to prevent significant hypoglycemia with early treatment is described.
低血糖是最常见的新生儿问题之一。尽管越来越多的证据表明低血糖与神经功能损害有关，但导致脑损伤的低血糖具体数值或持续时间仍不明确。目前发表的关于预防具有临床意义的低血糖的声明/指南相互矛盾，且仍基于低质量证据。本文综述了导致宫外血糖正常的过渡事件、导致短暂性或持续性低血糖的危险因素以及常见的治疗方法。还描述了与神经发育结局相关的当前信息以及通过早期治疗预防严重低血糖的筛查策略。
