State Key Laboratory of Food Science and Technology , University of Nanchang , Nanchang , Jiangxi 330047 , China.
Institute for Advanced Study , University of Nanchang , Nanchang , Jiangxi 330031 , China.
J Agric Food Chem. 2018 Dec 26;66(51):13492-13502. doi: 10.1021/acs.jafc.8b05137. Epub 2018 Nov 26.
Lotus seed epicarp (LSE) and lotus seed pot (LSP) were characterized, and a total of 5 and 7 proanthocyanidins (PAs) were identified in purified LSE and LSP extract, respectively. Purified LSE and LSP PAs significantly suppressed the body weight and weight gain of white adipose tissue (WAT) and decreased the WAT cell size in high-fat diet-induced obese mice regardless of the daily food intake. LSE or LSP administration significantly lowered the serum leptin level and improved the serum and liver lipid profiles (including total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels), increased activities of antioxidant enzymes (superoxide dismutase (SOD) and glutathione transferase (GST)) and reduced glutathione (GSH) concentration, and suppressed lipid peroxidation in hepatic tissue. LSP PAs were generally more effective than LSE PAs. Both extracts ameliorated obesity, insulin resistance, and oxidative damage in obese mice, suggesting they are good candidates for value-added functional food and nutraceutical ingredients.
莲籽种皮（LSE）和莲籽壳（LSP）的特性得到了描述，分别从纯化的 LSE 和 LSP 提取物中鉴定出了 5 种和 7 种原花青素（PAs）。纯化的 LSE 和 LSP PAs 显著抑制高脂肪饮食诱导肥胖小鼠的体重和白色脂肪组织（WAT）增重，并减小 WAT 细胞大小，而不论每日食物摄入量如何。LSE 或 LSP 给药显著降低血清瘦素水平，并改善血清和肝脏脂质谱（包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平），增加抗氧化酶（超氧化物歧化酶（SOD）和谷胱甘肽转移酶（GST））和还原型谷胱甘肽（GSH）浓度的活性，并抑制肝组织中的脂质过氧化。LSP PAs 通常比 LSE PAs 更有效。两种提取物均改善了肥胖、胰岛素抵抗和肥胖小鼠的氧化损伤，表明它们是增值功能性食品和营养保健品的良好候选物。
