Qiu Xiaoyan, Xiao Xiong, Li Nan, Ling Wenhui, Wang Mingyu, Li Yuemin
College of Animal Science and Technology, Southwest University, 2 Tian Sheng Street, BeiBei, Chong Qing 400715, P. R. China.
Reprod Fertil Dev. 2019 Apr;31(4):743-750. doi: 10.1071/RD18069.
In a previous study we investigated the association between two single nucleotide polymorphism (SNP) genotypes, namely steroid 17-alpha-hydroxylase/17,20 lyase (CYP17) SNP628 and dopamine receptor D2 (DRD2) SNP939, with two temperaments (calm and nervous) in Australian Merino sheep and concluded that the DRD2 SNP939 T/T genotype combined with the CYP17 SNP628 G/G genotype is associated with a calm temperament and could be used as a potential marker for calm sheep, whereas the DRD2 SNP939C allele combined with the CYP17 SNP628 A/A genotype is associated with a nervous temperament and could be used as a potential marker for nervous sheep. In sheep, the association between temperament and reproductive performance has been determined, but the association of these two SNP genotypes with sheep reproduction has not been investigated. Therefore, using Chinese Sinkiang Merino sheep, the present study investigated the association of the two CYP17 SNP628 and DRD2 SNP939 genotypes with sheep reproductive performance. Sheep with the DRD2 SNP939 T/T genotype combined with the CYP17 SNP628 G/G genotype had a higher ovulation rate, multiple gestation rate, better maternal behaviour and lower lamb mortality. Thus, the results of this study contribute to our knowledge of the association between genotypes and reproduction in sheep, which is beneficial for sheep genetics and breeding.
在之前的一项研究中，我们调查了两种单核苷酸多态性（SNP）基因型，即类固醇17-α-羟化酶/17,20裂解酶（CYP17）SNP628和多巴胺受体D2（DRD2）SNP939，与澳大利亚美利奴绵羊两种性情（温顺和神经质）之间的关联，并得出结论：DRD2 SNP939 T/T基因型与CYP17 SNP628 G/G基因型相结合与温顺性情相关，可作为温顺绵羊的潜在标记，而DRD2 SNP939 C等位基因与CYP17 SNP628 A/A基因型相结合与神经质性情相关，可作为神经质绵羊的潜在标记。在绵羊中，性情与繁殖性能之间的关联已得到确定，但这两种SNP基因型与绵羊繁殖的关联尚未得到研究。因此，本研究以中国新疆美利奴绵羊为对象，调查了CYP17 SNP628和DRD2 SNP939这两种基因型与绵羊繁殖性能的关联。具有DRD2 SNP939 T/T基因型与CYP17 SNP628 G/G基因型相结合的绵羊具有更高的排卵率、多胎妊娠率、更好的母性行为和更低的羔羊死亡率。因此，本研究结果有助于我们了解绵羊基因型与繁殖之间的关联，这对绵羊遗传学和育种有益。
