Gebhardt C, Leisch F, Schüssler P, Fuchs K, Stompe T, Sieghart W, Hornik K, Kasper S, Aschauer H N
Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria.
Psychiatr Genet. 2000 Sep;10(3):131-7. doi: 10.1097/00041444-200010030-00005.
Recently, different research groups reported conflicting results with regard to an association of dopamine 4 receptor (DRD4) genotypes and the personality dimension of novelty seeking (NS). High scores for NS seemed to be associated with long alleles of a DRD4 polymorphism. Furthermore, an association between personality traits and the dopamine 2 (DRD2) receptor gene was reported. NS and persistence (PS) high scores seemed to be associated with alleles of DRD2. We examined 109 (78 female and 31 male) normal healthy individuals using Cloninger's Temperament and Character Inventory (TCI) in order to replicate these findings. We genotyped a 48 base pair variable number of tandem repeats (from two to eight repeats) polymorphism in the third exon of DRD4 and a Cys311Ser polymorphism in exon 7 of DRD2. We tested alleles and genotypes of DRD4 (allele 7 absent or present; genotype 4,4 versus 4,7), and Ser/Cys and Cys/Cys genotypes of DRD2 for associations with TCI values. NS and the alleles and genotypes of DRD4 did not show any association. In associating the genotypes of DRD2 with TCI scales (NS, harm avoidance, reward dependence and PS), we also found no association. Recent findings associating NS with DRD4 could not be replicated. With regard to DRD2, we tested a different polymorphism as published recently and could not find an association of TCI scales with the gene. The present results therefore do not provide evidence that the DRD2 and DRD4 receptor genes contribute a common and relevant effect to personality traits.
最近，不同的研究小组报告了关于多巴胺4受体（DRD4）基因型与寻求新奇（NS）人格维度之间关联的相互矛盾的结果。NS得分高似乎与DRD4多态性的长等位基因有关。此外，还报道了人格特质与多巴胺2（DRD2）受体基因之间的关联。NS和坚持性（PS）得分高似乎与DRD2的等位基因有关。我们使用克隆宁格的气质和性格量表（TCI）对109名（78名女性和31名男性）正常健康个体进行了检查，以重复这些发现。我们对DRD4第三外显子中一个48个碱基对的串联重复可变数目（从两个到八个重复）多态性以及DRD2第七外显子中的Cys311Ser多态性进行了基因分型。我们测试了DRD4的等位基因和基因型（等位基因7存在或不存在；基因型4,4与4,7），以及DRD2的Ser/Cys和Cys/Cys基因型与TCI值之间的关联。NS与DRD4的等位基因和基因型未显示任何关联。在将DRD2的基因型与TCI量表（NS、避免伤害、奖赏依赖和PS）相关联时，我们也未发现关联。最近关于NS与DRD4相关的发现无法重复。关于DRD2，我们测试了最近发表的一种不同的多态性，未发现TCI量表与该基因存在关联。因此，目前的结果并未提供证据表明DRD2和DRD4受体基因对人格特质有共同且相关的影响。
