Sim Felix, Leidner Rom, Bell Richard Bryan
Department of Oral and Maxillofacial Surgery, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Department of Oral and Maxillofacial Surgery, Monash Health, 823 Centre Road, Bentleigh East, Victoria 3165, Australia; Oral and Maxillofacial Surgery Unit, Barwon Health, Ryrie Street & Bellerine Street, Geelong, Victoria 3220, Australia.
Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, Providence Cancer Institute, 4805 Northeast Glisan Street, Suite 2N35, Portland, OR 97213, USA.
Oral Maxillofac Surg Clin North Am. 2019 Feb;31(1):85-100. doi: 10.1016/j.coms.2018.09.002.
The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.
免疫系统在头颈部鳞状细胞癌（HNSCC）的发生、发展及进展过程中起着至关重要的作用。癌细胞的免疫逃逸导致HNSCC进展。对这一机制的理解为改善患者治疗方法及治疗效果奠定了基础。通过肿瘤对微环境的影响，免疫系统可被利用来促进转移、血管生成和生长。本文概述了肿瘤微环境中免疫浸润细胞之间的相互作用以及与HNSCC相关的免疫学原理。还介绍了当前的免疫治疗策略以及正在进行的临床试验的最新结果。
