Venkatesiah Sowmya Samudrala, Augustine Dominic, Mishra Deepika, Gujjar Neethi, Haragannavar Vanishri C, Awan Kamran Habib, Patil Shankargouda
Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru 560054, India.
Department of Oral Pathology & Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), Delhi 110608, India.
Life (Basel). 2022 Nov 7;12(11):1807. doi: 10.3390/life12111807.
This review aims to understand the concept of oral cancer immunology through the notion of immune profiling, immunoediting and immunotherapy, and to gain knowledge regarding its application for the management of oral cancer patients. Oral cancer is an immunogenic tumor where the cells of the tumor microenvironment play an important role in tumorigenesis. Understanding the mechanism of these modulations can help design immunotherapeutic strategies in oral cancer patients. This article gives an overview of immunomodulation in the oral cancer tumor microenvironment, with concepts of immune profiling, immunoediting and immunotherapy. English literature searches via Google Scholar, Web of Science, EBSCO, Scopus, and PubMed database were performed with the key words immunology, tumor microenvironment, cells, cross talk, immune profiling, biomarkers, inflammation, gene expression, techniques, immunoediting, immunosurveillance, tumor escape, immunotherapy, immune checkpoint inhibitors, vaccines in cancer, oral cancer, and head and neck cancer. Original research articles, reviews, and case reports published from 2016-2021 (n = 81) were included to appraise different topics, and were discussed under the following subsections. Literature published on oral cancer immunology reveals that oral cancer immune profiling with appropriate markers and techniques and knowledge on immunoediting concepts can help design and play an effective role in immunotherapeutic management of oral cancer patients. An evaluation of oral cancer immunology helps to determine its role in tumorigenesis, and immunotherapy could be the emerging drift in the effective management of oral cancer.
本综述旨在通过免疫谱分析、免疫编辑和免疫治疗的概念来理解口腔癌免疫学的概念，并获取有关其在口腔癌患者管理中的应用知识。口腔癌是一种免疫原性肿瘤，肿瘤微环境中的细胞在肿瘤发生中起重要作用。了解这些调节机制有助于设计针对口腔癌患者的免疫治疗策略。本文概述了口腔癌肿瘤微环境中的免疫调节，以及免疫谱分析、免疫编辑和免疫治疗的概念。通过谷歌学术、科学网、EBSCO、Scopus和PubMed数据库进行英文文献检索，关键词为免疫学、肿瘤微环境、细胞、相互作用、免疫谱分析、生物标志物、炎症、基因表达、技术、免疫编辑、免疫监视、肿瘤逃逸、免疫治疗、免疫检查点抑制剂、癌症疫苗、口腔癌和头颈癌。纳入了2016年至2021年发表的原创研究文章、综述和病例报告（n = 81）以评估不同主题，并在以下子节中进行讨论。关于口腔癌免疫学的文献表明，使用适当的标志物和技术进行口腔癌免疫谱分析以及对免疫编辑概念的了解有助于设计并在口腔癌患者的免疫治疗管理中发挥有效作用。对口腔癌免疫学的评估有助于确定其在肿瘤发生中的作用，而免疫治疗可能是口腔癌有效管理中的新兴趋势。
