Karadeniz Muhammed, Sarak Taner, Duran Mustafa, Alp Caglar, Kandemir Huseyin, Etem Celik İbrahim, Simsek Vedat, Kılıc Alparslan
Department of Cardiology, Kırıkkale University, Yahşihan 71450, Kırıkkale.
Department of Cardiology, Ankara Education and Research Hospital, Altındag 06230, Ankara, Turkey.
Acta Cardiol Sin. 2018 Nov;34(6):458-463. doi: 10.6515/ACS.201811_34(6).20180528B.
Hyperhomocysteinemia is a known risk factor for acute coronary syndrome (ACS) and is related with the severity of coronary artery disease (CAD). Previous studies have used less quantifiable scoring systems for assessing the severity of CAD. Therefore, we aimed to assess the relationship between homocysteine levels and SYNTAX score (SXscore), which is currently more widely used to grade the severity of CAD.
A total of 503 patients with adiagnosis of ACS were examined angiographically with SXscore. The patients were divided into three groups according to SXscore; Group 1 a low SXscore (≤ 22), Group 2 a moderate SXscore (23-32), and Group 3 a high SXscore (≥ 33).
Plasma homocysteine levels were 16.3 ± 6.2 nmol/mL in Group 1, 18.1 ± 9.6 nmol/mL in Group 2, and 19.9 ± 9.5 nmol/mL in Group 3. Homocysteine levels were significantly higher in Group 2, and Group 3 compared to Group 1 (p = 0.023 and 0.007, respectively). In the correlation analysis, homocysteine levels were correlated with SXscore (r: 0.166, p < 0.01).
Serum homocysteine levels on admission were associated with an increased severity of CAD in the patients with ACS.
高同型半胱氨酸血症是急性冠状动脉综合征（ACS）的已知危险因素，且与冠状动脉疾病（CAD）的严重程度相关。以往的研究使用的是量化程度较低的评分系统来评估CAD的严重程度。因此，我们旨在评估同型半胱氨酸水平与SYNTAX评分（SXscore）之间的关系，SYNTAX评分目前被更广泛地用于对CAD的严重程度进行分级。
共有503例诊断为ACS的患者接受了SXscore血管造影检查。根据SXscore将患者分为三组；第1组为低SXscore（≤22），第2组为中等SXscore（23 - 32），第3组为高SXscore（≥33）。
第1组血浆同型半胱氨酸水平为16.3±6.2 nmol/mL，第2组为18.1±9.6 nmol/mL，第3组为19.9±9.5 nmol/mL。与第1组相比，第2组和第3组的同型半胱氨酸水平显著更高（分别为p = 0.023和0.007）。在相关性分析中，同型半胱氨酸水平与SXscore相关（r：0.166，p < 0.01）。
入院时血清同型半胱氨酸水平与ACS患者CAD严重程度增加相关。
