Shenoy Vijetha, Mehendale Veena, Prabhu Krishnananda, Shetty Ranjan, Rao Pragna
Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
Department of Applied Nutrition, Dietics Welcome Group School of Hotel Management, Manipal University, Manipal, India.
Indian J Clin Biochem. 2014 Jul;29(3):339-44. doi: 10.1007/s12291-013-0373-5. Epub 2013 Aug 31.
Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD.
冠状动脉疾病（CAD）已成为全球最常见的死亡原因。同型半胱氨酸被认为是早期动脉粥样硬化的促进因素。我们研究了血清同型半胱氨酸水平与冠状动脉疾病严重程度之间的关系。共有70名计划进行冠状动脉造影的受试者同意参与本研究。在所有患者中，采用Gensini评分系统评估CAD的严重程度。在血管造影术前，于空腹状态下采集患者的静脉血样。采用酶联免疫吸附法测量患者的同型半胱氨酸水平，并将其与参与者各自的Genseni评分进行比较。CAD患者的空腹血清同型半胱氨酸水平显著高于无冠状动脉疾病的患者（p < 0.001）。此外，同型半胱氨酸水平与CAD严重程度的增加显著相关（p < 0.001）。血清同型半胱氨酸水平与CAD的严重程度密切相关。
