Leong Teng I, Weiland Tracey J, Jelinek George A, Simpson Steve, Brown Chelsea R, Neate Sandra L, Taylor Keryn L, O'Kearney Emily, Milanzi Elasma, De Livera Alysha M
Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Front Neurol. 2018 Nov 2;9:874. doi: 10.3389/fneur.2018.00874. eCollection 2018.
To explore the association between combined lifestyle risk factors with quality of life in people with multiple sclerosis (MS) over 2.5 years. People with MS were recruited to participate in a comprehensive online survey regarding their demographic and clinical characteristics, health-related quality of life (HRQOL), and lifestyle behaviors including physical activity, alcohol consumption, cigarette smoking, body mass index, and dietary habits measured at baseline and 2.5-year follow-up. A combined healthy lifestyle index score (HLIS) was constructed by assigning scores of 0-4 to each of the lifestyle risk factors, for which higher values indicate healthier lifestyle behavior. Multivariable linear regression modeling was used to assess whether the HLIS at baseline was associated with the physical and mental HRQOL over the study period in this sample of people with MS. Of 2,466 participants with confirmed MS, 1,401 (57%) completed the follow-up. Multivariable linear regression analyses demonstrated that every 5-point increase (of a possible total of 20) in the baseline HLIS was associated with 1.7 (95% CI: 0.2-3.2) and 2.5 (95% CI: 1.0-4.0) higher scores in the change in physical and mental HRQOL components from baseline to follow-up respectively. Findings suggest the importance of healthy lifestyle behavior in quality of life in MS. A healthy lifestyle program focusing on these behaviors has the potential to positively influence health-related quality of life for people with MS.
为探究2.5年期间多发性硬化症（MS）患者的综合生活方式风险因素与生活质量之间的关联。招募MS患者参与一项关于其人口统计学和临床特征、健康相关生活质量（HRQOL）以及生活方式行为的综合在线调查，这些生活方式行为包括在基线期和2.5年随访期测量的身体活动、饮酒、吸烟、体重指数和饮食习惯。通过为每个生活方式风险因素赋予0 - 4分来构建综合健康生活方式指数得分（HLIS），得分越高表明生活方式行为越健康。使用多变量线性回归模型来评估在该MS患者样本中，基线期的HLIS是否与研究期间的身体和心理HRQOL相关。在2466名确诊为MS的参与者中，1401名（57%）完成了随访。多变量线性回归分析表明，基线HLIS每增加5分（满分可能为20分），从基线到随访期间身体和心理HRQOL组成部分的变化得分分别高出1.7分（95%置信区间：0.2 - 3.2）和2.5分（95%置信区间：1.0 - 4.0）。研究结果表明健康的生活方式行为对MS患者生活质量的重要性。专注于这些行为的健康生活方式计划有可能对MS患者的健康相关生活质量产生积极影响。
