Maurin N
Department of Internal Medicine II, University Clinic, RWTH Aachen, FRG.
Int J Artif Organs. 1988 Jul;11(4):243-8.
A serious disadvantage of preventing clot formation by using prostacyclin (PGI2) to inhibit thrombocyte function during dialysis is that there exists no rapidly measurable monitoring parameter. The "in vitro bleeding time" (in vitro BT) is a new method for measuring primary hemostasis in vitro. Five chronic dialysis patients each underwent two dialyses: 1) with conventional full heparinization, and 2) with the stable PGI2 analogue CG 4203 and additional "low-dose" heparin. The predialytic in vitro BT is longer than normal values and values 1 h after the end of dialysis. While heparin has no significant effect on the in vitro BT, CG 4203 prolongs it concentration-dependently. Infusing CG 4203 at a rate of 25 ng/kg/min, the in vitro BT is extended beyond the measurable range of 800 microliter during the first approx. 150 min of dialysis. During the next approx. 90 min it steadily decreases.
在透析过程中使用前列环素（PGI2）抑制血小板功能来防止血栓形成的一个严重缺点是不存在快速可测量的监测参数。“体外出血时间”（in vitro BT）是一种体外测量初级止血的新方法。五名慢性透析患者每人接受了两次透析：1）采用常规全量肝素化；2）使用稳定的PGI2类似物CG 4203及额外的“低剂量”肝素。透析前的体外出血时间长于正常值以及透析结束后1小时的值。虽然肝素对体外出血时间没有显著影响，但CG 4203会使其浓度依赖性延长。以25 ng/kg/min的速率输注CG 4203时，在透析的最初约150分钟内，体外出血时间延长至超过800微升的可测量范围。在接下来的约90分钟内，它会稳步下降。
