Rutgers Graduate School of Biomedical Sciences, Rutgers - The State University of New Jersey, Newark, NJ, USA.
Center for Immunity and Inflammation, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers - The State University of New Jersey, Newark, NJ, USA.
Immunology. 2019 Feb;156(2):111-119. doi: 10.1111/imm.13017. Epub 2018 Nov 18.
Natural killer (NK) cells are highly specialized cytotoxic lymphocytes that provide protection against pathogens and malignant cells. They develop from common lymphoid progenitors via a multi-stage lineage commitment and differentiation process that gives rise to mature NK cells with potent cytotoxic functionality. Although generally considered cells of the innate immune system, recent studies have demonstrated that NK cells have the capacity to mount immune responses with features of adaptive immunity, including robust antigen-specific clonal-like expansion and the generation of long-lived memory cells that mediate enhanced recall responses. Here, we discuss specific transcription factors that have been shown to commonly and uniquely regulate NK cell development and effector and memory responses in experimental mouse models.
自然杀伤 (NK) 细胞是高度特化的细胞毒性淋巴细胞，可提供针对病原体和恶性细胞的保护。它们由共同的淋巴祖细胞通过多阶段的谱系定向和分化过程发育而来，产生具有强大细胞毒性功能的成熟 NK 细胞。尽管通常被认为是先天免疫系统的细胞，但最近的研究表明，NK 细胞具有产生具有适应性免疫特征的免疫反应的能力，包括强大的抗原特异性克隆样扩增和产生介导增强的回忆反应的长寿记忆细胞。在这里，我们讨论了已显示在实验性小鼠模型中共同且独特地调节 NK 细胞发育以及效应和记忆反应的特定转录因子。
