a Department of Gynecology and Obstetrics, Peking Union Medical College Hospital , Peking Union Medical College , Beijing , People's Republic of China.
b Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and School of Basic Medicine , Peking Union Medical College , Beijing , People's Republic of China.
Climacteric. 2019 Feb;22(1):79-84. doi: 10.1080/13697137.2018.1520824. Epub 2018 Nov 19.
This study aimed to assess the prevalence and factors associated with symptomatic pelvic organ prolapse (POP) in a representative sample of postmenopausal Chinese women.
A total of 20,008 postmenopausal Chinese women were recruited to this cross-sectional study between February 2014 and March 2016. The prevalence of symptomatic POP, defined as any stage II or higher POP resulting in symptoms, was assessed using questionnaires and physical examinations. Multivariable logistic regression was used to assess factors associated with symptomatic POP.
Among all women with natural menopause included in the study (mean age =61.98 ± 10.62 years), 2962 of 20,008 women (14.80%, 95% confidence interval [CI] 14.3-15.3%) had symptomatic POP. In the multivariate analysis, women were more likely to have symptomatic POP if aged 50-59 years (adjusted odds ratio [AOR] 1.322, 95% CI 1.123-1.560), 60-69 years (AOR 1.603, 95% CI 1.352-1.907), or above 70 years (AOR 1.824, 95% CI 1.158-2.197), compared with women aged 40-49 years. Having delivered two times (AOR 1.145, 95% CI 1.105-1.292) or three or more times (AOR 1.384, 95% CI 1.214-1.578) was significantly associated with symptomatic POP. Compared with normal weight women, overweight women (AOR 1.365, 95% CI 1.247-1.494) and obese women (AOR 1.548, 95% CI 1.344-1.780) were more likely to have POP. Living in an urban area, smoking, alcohol consumption, cough, constipation, mental labor, physical disease, and gynecological diseases were also associated with symptomatic POP.
Symptomatic POP affects nearly 15% of postmenopausal women in China. The prevalence of symptomatic POP increases significantly with age, body mass index, and parity.
本研究旨在评估中国绝经后女性代表性样本中症状性盆腔器官脱垂（POP）的患病率和相关因素。
本横断面研究于 2014 年 2 月至 2016 年 3 月期间招募了 20008 名绝经后中国女性。采用问卷和体格检查评估有症状 POP（定义为任何 II 期或更高阶段 POP 导致症状）的患病率。多变量 logistic 回归用于评估与症状性 POP 相关的因素。
在纳入研究的所有自然绝经女性中（平均年龄=61.98±10.62 岁），20008 名女性中有 2962 名（14.80%，95%置信区间[CI]14.3-15.3%）患有症状性 POP。多变量分析显示，与 40-49 岁年龄组相比，50-59 岁（调整后的优势比[OR]1.322，95%CI1.123-1.560）、60-69 岁（OR1.603，95%CI1.352-1.907）或 70 岁以上（OR1.824，95%CI1.158-2.197）的女性更有可能出现症状性 POP。分娩两次（OR1.145，95%CI1.105-1.292）或三次或更多次（OR1.384，95%CI1.214-1.578）与症状性 POP 显著相关。与正常体重女性相比，超重女性（OR1.365，95%CI1.247-1.494）和肥胖女性（OR1.548，95%CI1.344-1.780）更有可能患有 POP。居住在城市地区、吸烟、饮酒、咳嗽、便秘、脑力劳动、身体疾病和妇科疾病也与症状性 POP 相关。
在中国，近 15%的绝经后女性患有症状性 POP。症状性 POP 的患病率随着年龄、体重指数和产次的增加而显著增加。
