人类胃肠道肿瘤中线粒体相关的21×10³道尔顿蛋白质含量增加。
Increased amount of a mitochondria-associated 21 x 10(3) dalton protein in human gastrointestinal tumors.
作者信息
Welter C, Reichert G, Zang K D
机构信息
Institute of Human Genetics, University of the Saar, Homburg/Saar, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1988;114(4):411-4. doi: 10.1007/BF02128187.
Abstract
Differences in the structure and number of mitochondria in tumor cells were found. Using isoelectrofocusing two-dimensional polyacrylamide gel electrophoresis which allows detection of alterations in the protein pattern of tumor mitochondria, we studied both quantitative and qualitative changes in the mitochondrial protein pattern of human gastrointestinal tumors and corresponding normal matrix tissues. One low molecular protein spot was found to be quantitatively changed in the tumors. The approximate molecular weight was 21 x 10(3) daltons and the pI value 5.7.
摘要
发现肿瘤细胞中线粒体的结构和数量存在差异。利用等电聚焦二维聚丙烯酰胺凝胶电泳（可检测肿瘤线粒体蛋白质模式的变化），我们研究了人类胃肠道肿瘤及相应正常基质组织中线粒体蛋白质模式的定量和定性变化。发现一个低分子蛋白质斑点在肿瘤中发生了定量变化。其近似分子量为21×10³道尔顿，pI值为5.7。
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