手性二烯和氧化膦的对映选择性偶联。
Enantioselective Coupling of Dienes and Phosphine Oxides.
机构信息
Department of Chemistry , University of California , Irvine , California 92697 , United States.
College of Pharmacy , Liaocheng University , Liaocheng , Shandong 252059 , China.
出版信息
J Am Chem Soc. 2018 Dec 5;140(48):16450-16454. doi: 10.1021/jacs.8b11150. Epub 2018 Nov 19.
Abstract
We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes.
摘要
我们报告了一种 Pd 催化的 1,3-二烯的分子间氢膦化反应，得到手性烯丙基膦氧化物。商品二烯和空气稳定的磷氧化物偶联，以高对映选择性和区域选择性生成有机磷砌块。该方法构成了首例不对称二烯氢膦化反应。
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