Bagheri Mohammad Javad, Talebpour Mohammad, Sharifi Amirsina, Talebpour Atieh, Mohseni Alireza
a Department of Surgery , Hazrat-e-Rasool Akram Hospital, Iran University of Medical Sciences , Tehran , Iran.
b Department of Surgery , Laparoscopic Ward, Sina Hospital, Tehran University of Medical Sciences , Tehran , Iran.
Acta Chir Belg. 2019 Jun;119(3):146-151. doi: 10.1080/00015458.2018.1479022. Epub 2018 Nov 19.
Bariatric surgeries are known to have profound effects on lipid profile. Laparoscopic gastric plication (LGP) has been shown to have a comparable effect on weight loss rather than Roux-en-Y gastric bypass (RYGB) and mini gastric bypass (MGB). But the post-operative effect on lipid profile is not well-compared. We aimed to compare post-operative lipid profile change after LGP and MGB.
In a retrospective analysis, we reviewed 91 patients for at least 12 months. Patients were assigned to undergo either LGP (71 patients) or MGB (20 patients). Preoperative and postoperative visits were accomplished and weight, BMI, fasting blood glucose (FBG) and lipid profile including triglyceride (TG), and total cholesterol (TC) levels were repeatedly measured. Follow up rate for the first year was 100%.
LGP significantly decreased both TG and TC levels in each follow up (all p values < .05). The same trends were observed in BMI reduction, total body weight loss percentage, and FBG. When comparing either TC or TG level between LGP and MGB, there was just one statistically significant result in TG reduction at 6 months (p value = .042) while MGB showed more reduction. All other variables in different follow up visits were not significantly different between two techniques.
LGP would result in lipid profile improvement lasting at least for one year. Lipid-lowering effect seems to be similar between LGP and MGB. This lipid-lowering property and weight reduction might be indicative that LGP is an alternative for RYGB and MGB in selective patients.
已知减肥手术对血脂水平有深远影响。腹腔镜胃折叠术（LGP）已被证明在减肥效果上与 Roux-en-Y 胃旁路术（RYGB）和迷你胃旁路术（MGB）相当。但术后对血脂水平的影响尚未得到充分比较。我们旨在比较 LGP 和 MGB 术后血脂水平的变化。
在一项回顾性分析中，我们对 91 例患者进行了至少 12 个月的随访。患者被分配接受 LGP（71 例）或 MGB（20 例）。完成术前和术后访视，并反复测量体重、BMI、空腹血糖（FBG）和血脂水平，包括甘油三酯（TG）和总胆固醇（TC）水平。第一年的随访率为 100%。
LGP 在每次随访中均显著降低了 TG 和 TC 水平（所有 p 值<0.05）。在 BMI 降低、总体重减轻百分比和 FBG 方面也观察到了相同的趋势。在比较 LGP 和 MGB 之间的 TC 或 TG 水平时，仅在 6 个月时 TG 降低有一个统计学显著结果（p 值 = 0.042），而 MGB 的降低幅度更大。两种技术在不同随访中的所有其他变量均无显著差异。
LGP 可使血脂水平改善至少持续一年。LGP 和 MGB 的降脂效果似乎相似。这种降脂特性和体重减轻可能表明 LGP 是选择性患者中 RYGB 和 MGB 的替代方案。
