Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, Australia.
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
J Alzheimers Dis. 2018;66(4):1619-1633. doi: 10.3233/JAD-180439.
It has been reported that social engagement may be associated with dementia risk. We searched PubMed, EMBASE, PsycINFO, CINAHL, LILACS, Biomed Central, Scopus, and Web of Science from January 2012 - May 2017, supplemented by extraction from previous reviews. We included cohort and case-control studies examining the association between social engagement or loneliness and dementia risk, pooling data using a random-effects model. Registered: PROSPERO (CRD42017067074). We included 31 cohort and 2 case-control studies comprising 2,370,452 participants. Poor social engagement indices were associated with increased dementia risk, including having a poor social network (RR = 1.59, 95% CI 1.31-1.96; I2 = 0.00%) and poor social support (RR = 1.28, 95% CI 1.01-1.62; I2 = 55.51%). In long-term studies (≥10 years), good social engagement was modestly protective (RR = 0.88, 95% CI 0.80-0.96; I2 = 0.00%). Loneliness was non-significantly associated with increased risk (RR = 1.38, 95% CI 0.98-1.94; I2 = 45.32). Our findings encourage interventions targeting social isolation and disengagement for dementia prevention.
据报道，社交参与可能与痴呆风险相关。我们检索了 PubMed、EMBASE、PsycINFO、CINAHL、LILACS、Biomed Central、Scopus 和 Web of Science，时间范围为 2012 年 1 月至 2017 年 5 月，并补充了以前综述的提取内容。我们纳入了队列研究和病例对照研究，以检查社交参与或孤独与痴呆风险之间的关联，使用随机效应模型汇总数据。注册：PROSPERO（CRD42017067074）。我们纳入了 31 项队列研究和 2 项病例对照研究，共涉及 2370452 名参与者。较差的社交参与指数与痴呆风险增加相关，包括社交网络较差（RR=1.59，95%CI 1.31-1.96；I2=0.00%）和社会支持较差（RR=1.28，95%CI 1.01-1.62；I2=55.51%）。在长期研究（≥10 年）中，良好的社交参与适度具有保护作用（RR=0.88，95%CI 0.80-0.96；I2=0.00%）。孤独与风险增加无显著相关性（RR=1.38，95%CI 0.98-1.94；I2=45.32%）。我们的研究结果鼓励针对社交隔离和脱节的干预措施，以预防痴呆。
