社交参与、孤独感与痴呆风险之间的关联：系统评价和荟萃分析。
The Association between Social Engagement, Loneliness, and Risk of Dementia: A Systematic Review and Meta-Analysis.
机构信息
Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, Australia.
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
出版信息
J Alzheimers Dis. 2018;66(4):1619-1633. doi: 10.3233/JAD-180439.
It has been reported that social engagement may be associated with dementia risk. We searched PubMed, EMBASE, PsycINFO, CINAHL, LILACS, Biomed Central, Scopus, and Web of Science from January 2012 - May 2017, supplemented by extraction from previous reviews. We included cohort and case-control studies examining the association between social engagement or loneliness and dementia risk, pooling data using a random-effects model. Registered: PROSPERO (CRD42017067074). We included 31 cohort and 2 case-control studies comprising 2,370,452 participants. Poor social engagement indices were associated with increased dementia risk, including having a poor social network (RR = 1.59, 95% CI 1.31-1.96; I2 = 0.00%) and poor social support (RR = 1.28, 95% CI 1.01-1.62; I2 = 55.51%). In long-term studies (≥10 years), good social engagement was modestly protective (RR = 0.88, 95% CI 0.80-0.96; I2 = 0.00%). Loneliness was non-significantly associated with increased risk (RR = 1.38, 95% CI 0.98-1.94; I2 = 45.32). Our findings encourage interventions targeting social isolation and disengagement for dementia prevention.
据报道，社交参与可能与痴呆风险相关。我们检索了 PubMed、EMBASE、PsycINFO、CINAHL、LILACS、Biomed Central、Scopus 和 Web of Science，时间范围为 2012 年 1 月至 2017 年 5 月，并补充了以前综述的提取内容。我们纳入了队列研究和病例对照研究，以检查社交参与或孤独与痴呆风险之间的关联，使用随机效应模型汇总数据。注册：PROSPERO（CRD42017067074）。我们纳入了 31 项队列研究和 2 项病例对照研究，共涉及 2370452 名参与者。较差的社交参与指数与痴呆风险增加相关，包括社交网络较差（RR=1.59，95%CI 1.31-1.96；I2=0.00%）和社会支持较差（RR=1.28，95%CI 1.01-1.62；I2=55.51%）。在长期研究（≥10 年）中，良好的社交参与适度具有保护作用（RR=0.88，95%CI 0.80-0.96；I2=0.00%）。孤独与风险增加无显著相关性（RR=1.38，95%CI 0.98-1.94；I2=45.32%）。我们的研究结果鼓励针对社交隔离和脱节的干预措施，以预防痴呆。
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