Mitsui Yosuke, Sadahira Takuya, Araki Motoo, Maruyama Yuki, Wada Koichiro, Tanimoto Ryuta, Kobayashi Yasuyuki, Watanabe Masami, Watanabe Toyohiko, Nasu Yasutomo
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Jpn J Clin Oncol. 2019 Feb 1;49(2):183-189. doi: 10.1093/jjco/hyy166.
In several cancers, the loss of skeletal muscle is well associated with oncological outcome. However, its effect is unknown in testicular cancer. This study evaluated the prognostic impact of psoas major muscle volume loss during systemic chemotherapy.
This was a retrospective study of patients who underwent chemotherapy from 2008 to 2017. Psoas major muscle volume was calculated by volume analyzer software, and its loss was calculated during systemic chemotherapy. The patients were divided according to muscle volume loss: Group 1 (<20%) and Group 2 (≥20%). The losses were compared with Kaplan-Meier curves, and a Cox proportional hazard model was applied to test predictors of poor prognosis.
Fifty patients were included. Seventeen were classified into Group 1, and 33 into Group 2. The Kaplan-Meier curves revealed that the progression-free and the overall survival of Group 1 were significantly better than those of Group 2 (P = 0.002, P = 0.03, respectively). A multivariate analysis identified psoas major muscle volume loss as a significant and independent predictor of poor prognosis.
Patients with psoas major muscle volume loss during chemotherapy had a significantly worse prognosis than those without loss.
在几种癌症中，骨骼肌的减少与肿瘤学结局密切相关。然而，其在睾丸癌中的作用尚不清楚。本研究评估了全身化疗期间腰大肌体积减少的预后影响。
这是一项对2008年至2017年接受化疗患者的回顾性研究。通过体积分析仪软件计算腰大肌体积，并计算全身化疗期间的体积减少量。根据肌肉体积减少情况将患者分为两组：第1组（<20%）和第2组（≥20%）。采用Kaplan-Meier曲线比较两组的体积减少情况，并应用Cox比例风险模型测试预后不良的预测因素。
纳入50例患者。17例分为第1组，33例分为第2组。Kaplan-Meier曲线显示，第1组的无进展生存期和总生存期明显优于第2组（分别为P = 0.002，P = 0.03）。多因素分析确定腰大肌体积减少是预后不良的显著且独立预测因素。
化疗期间腰大肌体积减少的患者预后明显比未减少的患者差。
