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预防胜于治疗：理解意义未明的单克隆丙种球蛋白血症向骨髓瘤的转变。

Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma.

机构信息

Department of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA.

Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.

出版信息

Int J Mol Sci. 2018 Nov 16;19(11):3621. doi: 10.3390/ijms19113621.

DOI:10.3390/ijms19113621
PMID:30453544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6274834/
Abstract

Multiple myeloma is an invariably fatal cancer of plasma cells. Despite tremendous advances in treatment, this malignancy remains incurable in most individuals. We postulate that strategies aimed at prevention have the potential to be more effective in preventing myeloma-related death than additional pharmaceutical strategies aimed at treating advanced disease. Here, we present a rationale for the development of prevention therapy and highlight potential target areas of study.

摘要

多发性骨髓瘤是一种不可避免的致命浆细胞瘤癌。尽管在治疗方面取得了巨大进展，但这种恶性肿瘤在大多数个体中仍然无法治愈。我们假设，旨在预防的策略在预防骨髓瘤相关死亡方面可能比旨在治疗晚期疾病的额外药物策略更有效。在这里，我们提出了开发预防疗法的基本原理，并强调了潜在的研究目标领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/a187b4b865fe/ijms-19-03621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/dc38d6b1d73d/ijms-19-03621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/2b20739931e0/ijms-19-03621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/146303bf7583/ijms-19-03621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/a187b4b865fe/ijms-19-03621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/dc38d6b1d73d/ijms-19-03621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/2b20739931e0/ijms-19-03621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/146303bf7583/ijms-19-03621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/6274834/a187b4b865fe/ijms-19-03621-g004.jpg

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2
Value and Cost of Myeloma Therapy.骨髓瘤治疗的价值与成本
Am Soc Clin Oncol Educ Book. 2018 May 23;38:662-666. doi: 10.1200/EDBK_200867.
3
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.阿司匹林对健康老年人心血管事件和出血的影响。
抗糖尿病药物二甲双胍作用于骨微环境，促进骨髓瘤细胞与前成骨细胞的黏附，并增加体内骨髓瘤肿瘤负担。
Transl Oncol. 2022 Jan;15(1):101301. doi: 10.1016/j.tranon.2021.101301. Epub 2021 Dec 8.
4
[Progress of interleukin-6-related antibodies in the treatment of multiple myeloma].[白细胞介素-6相关抗体在多发性骨髓瘤治疗中的研究进展]
Zhonghua Xue Ye Xue Za Zhi. 2021 Jun 14;42(6):525-528. doi: 10.3760/cma.j.issn.0253-2727.2021.06.017.
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