Top Institute of Food and Nutrition, P.O. Box 557, 6700 AN Wageningen, The Netherlands.
Division of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Nutrients. 2018 Nov 17;10(11):1787. doi: 10.3390/nu10111787.
Activation of the intestinal brake by infusing nutrients into the distal small intestine with catheters inhibits food intake and enhances satiety. Encapsulation of macronutrients, which protects against digestion in the proximal gastrointestinal tract, can be a non-invasive alternative to activate this brake. In this study, we investigate the effect of oral ingestion of an encapsulated casein and sucrose mixture (active) targeting the distal small intestine versus a control product designed to be released in the stomach on food intake, satiety, and plasma glucose concentrations. Fifty-nine volunteers received the active and control product on two separate test days. Food intake was determined during an meal 90 min after ingestion of the test product. Visual analogue scale scores for satiety and blood samples for glucose analysis were collected at regular intervals. Ingestion of the active product decreased food intake compared to the control product (655 kcal compared with 699 kcal, respectively, < 0.05). The area under the curve (AUC) for hunger was decreased ( < 0.05) and AUC for satiety was increased ( < 0.01) after ingestion of the active product compared to the control product. Ingestion of an encapsulated protein-carbohydrate mixture resulted in inhibition of food intake compared to a non-encapsulated control product.
通过向远端小肠内输注营养物质并用导管激活肠道制动，可抑制摄食并增强饱腹感。将宏量营养素包埋（使其免受上消化道消化）可作为一种非侵入性替代方法来激活这种制动。在这项研究中，我们研究了口服靶向远端小肠的包被酪蛋白和蔗糖混合物（活性）与旨在在胃中释放的对照产品对摄食、饱腹感和血浆葡萄糖浓度的影响。59 名志愿者在两个单独的测试日接受了活性和对照产品。在摄入测试产品后 90 分钟进行了餐食期间的摄食测定。定期采集用于评估饱腹感的视觉模拟量表评分和用于葡萄糖分析的血样。与对照产品相比，摄入活性产品可减少食物摄入量（分别为 655 千卡和 699 千卡， < 0.05）。与对照产品相比，摄入活性产品后，饥饿的曲线下面积（AUC）降低（ < 0.05），饱腹感的 AUC 增加（ < 0.01）。与非包埋对照产品相比，摄入包埋的蛋白质-碳水化合物混合物可抑制食物摄入。
