Shen Bao-de, Shen Cheng-Ying, Xu Ling-Xia, Zhu Wei-Feng, Yuan Hai-Long
Key Laboratory of Modern Preparation of Traditional Chinese Medicine (TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China.
Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China.
Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(19):3828-3833. doi: 10.19540/j.cnki.cjcmm.20180726.017.
Nanosuspension (also called nanocrystal suspension or nanocrystal) could significantly enhance the saturated solubility and dissolution of insoluble drugs, and improve their bioavailability by reducing particle size and increasing the specific surface, which could then solve the delivery problems of the poorly soluble active ingredients and effective parts of Chinese materia medica (CMM). Based on the brief summaries of nanosuspension preparation methods, this paper would mainly review the and behaviors of poorly soluble CMM nanosuspension, discuss and analyze its problems, so as to provide reference and thinking for the further study of nanosuspension drug delivery system of poorly soluble CMM and promote the development and perfection of nanosuspension technology in CMM.
纳米混悬液（也称为纳米晶体混悬液或纳米晶体）可显著提高难溶性药物的饱和溶解度和溶出度，并通过减小粒径和增加比表面积来提高其生物利用度，进而解决难溶性中药有效成分和有效部位的给药问题。基于纳米混悬液制备方法的简要概述，本文将主要综述难溶性中药纳米混悬液的[此处原文缺失两个词]行为，讨论并分析其存在的问题，以便为难溶性中药纳米混悬液给药系统的进一步研究提供参考和思路，促进中药纳米混悬液技术的发展与完善。
