Key Laboratory of Chinese Materia Medica (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China; Department of Pharmacy, Heilongjiang Nursing College, 209 Academy Road, Harbin, 150086, PR China.
Key Laboratory of Chinese Materia Medica (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China.
J Ethnopharmacol. 2021 Apr 6;269:113558. doi: 10.1016/j.jep.2020.113558. Epub 2020 Nov 10.
Asthma is a costly global health problem that negatively influences the quality of life of patients. The Chinese Materia Medica (CMM) contains remedies that have been used for the treatment of asthma for millennia. This article strives to systematically summarize the current research progress so that more comprehensive examinations of various databases related to CMM anti-asthma drugs, can be performed, so as to sequentially provide effective basic data for development and application of anti-asthma drugs based on the CMM.
The research data published over the past 20 years for asthma treatment based on traditional CMM remedies were retrieved and collected from libraries and online databases (PubMed, ScienceDirect, Elsevier, Spring Link, Web of Science, PubChem Compound, Wan Fang, CNKI, Baidu, and Google Scholar). Information was also added from classic CMM, literature, conference papers on classic herbal formulae, and dissertations (PhD or Masters) based on traditional Chinese medicine.
This review systematically summarizes the experimental studies on the treatment of asthma with CMM, covering the effective chemical components, typical asthma models, important mechanisms and traditional anti-asthma CMM formulae. The therapy value of the CMM for anti-asthma is clarified, and the original data and theoretical research foundation are provided for the development of new anti-asthmatic data and research for the CMM.
Substantial progress against asthma has been made through relevant experimental research based on the CMM. These advances improved the theoretical basis of anti-asthma drugs for CMM and provided a theoretical basis for the application of a asthma treatment that is unique. By compiling these data, it is expected that the CMM will now contain a clearer mechanism of action and a greater amount of practical data that can be used for future anti-asthma drug research.
哮喘是一个代价高昂的全球性健康问题，会对患者的生活质量产生负面影响。中药（CMM）中包含了数千年来用于治疗哮喘的药物。本文旨在系统地总结当前的研究进展，以便更全面地检查与 CMM 抗哮喘药物相关的各种数据库，从而为基于 CMM 的抗哮喘药物的开发和应用提供更全面的基础数据。
从图书馆和在线数据库（PubMed、ScienceDirect、Elsevier、Spring Link、Web of Science、PubChem Compound、Wan Fang、CNKI、Baidu 和 Google Scholar）检索并收集了过去 20 年来基于传统 CMM 疗法治疗哮喘的研究数据。此外，还从经典 CMM、文献、经典草药方剂会议论文和中药博士或硕士论文中添加了信息。
本综述系统地总结了 CMM 治疗哮喘的实验研究，涵盖了有效化学成分、典型哮喘模型、重要机制和传统抗哮喘 CMM 配方。阐明了 CMM 治疗哮喘的治疗价值，为开发新的抗哮喘 CMM 数据和研究提供了原始数据和理论研究基础。
通过基于 CMM 的相关实验研究，在治疗哮喘方面取得了实质性进展。这些进展改善了 CMM 抗哮喘药物的理论基础，并为独特的哮喘治疗应用提供了理论基础。通过编译这些数据，预计 CMM 现在将包含更清晰的作用机制和更多的实际数据，可用于未来的抗哮喘药物研究。
