NRRL 1386 对异冠瘿蚊素 D 的微生物转化。

Microbial transformation of isocoronarin D by NRRL 1386.

机构信息

a Department of Chemistry, School of Science, University of Phayao , Muang , Phayao , Thailand.

b Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University , Bangkok , Thailand.

出版信息

Nat Prod Res. 2019 Oct;33(20):2890-2896. doi: 10.1080/14786419.2018.1509331. Epub 2018 Nov 20.

DOI:10.1080/14786419.2018.1509331

PMID:30453782

Abstract

The diterpene isocoronarin D () is a bioactive major constituent of labdane diterpene from the aerial parts of Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of was performed by the fungus NRRL 1386 to yield three new metabolites, 3-hydroxyisocoronarin D (), 6-hydroxyisocoronarin D () and 3,7-dihydroxyisocoronarin D (). The structures of the new compounds were elucidated by spectroscopic techniques.

摘要

异 Coronarin D（）是姜科植物罗勒（）地上部分的拉宾二萜中的一种生物活性主要成分。通过真菌 NRRL 1386 对进行微生物转化，生成了三种新的代谢产物：3-羟基异 Coronarin D（）、6-羟基异 Coronarin D（）和 3,7-二羟基异 Coronarin D（）。通过光谱技术阐明了新化合物的结构。