菖蒲科姜黄属植物地上部分的贝壳杉烷二萜能提高红系细胞中胎儿血红蛋白的生成。

Labdane diterpenes from the aerial parts of Curcuma comosa enhance fetal hemoglobin production in an erythroid cell line.

机构信息

Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.

出版信息

J Nat Prod. 2010 Apr 23;73(4):724-8. doi: 10.1021/np900568k.

DOI:10.1021/np900568k

PMID:20196571

Abstract

Three new labdane diterpenes, curcucomosins A-C (1-3), four known labdane diterpenes, 4-7, and a known diarylheptanoid, 8, were isolated from the aerial parts of Curcuma comosa. The structures of the new diterpenes were elucidated by spectroscopic data analysis. The fetal hemoglobin (Hb F) induction potency of the isolated compounds was examined using a K562 reporter cell line harboring the enhanced green fluorescence protein (EGFP) gene under the control of a (G)gamma-globin promoter. Compound 6, isocoronarin D, exhibited the highest Hb F induction effect of 1.6-fold at 20 microM.

摘要

从姜黄属植物的地上部分分离得到了三种新的角鲨烷二萜，即 curcucomosins A-C（1-3），四种已知的角鲨烷二萜，4-7，以及一种已知的二芳基庚烷，8。通过光谱数据分析阐明了新二萜的结构。使用 K562 报告细胞系，该细胞系带有在（G）γ-珠蛋白启动子控制下的增强型绿色荧光蛋白（EGFP）基因，检测了分离化合物的胎儿血红蛋白（Hb F）诱导能力。化合物 6，异 Coronarin D，在 20 μM 时表现出最高的 Hb F 诱导作用，为 1.6 倍。