Center for Comparative Effectiveness Research & Economic Evaluation in Korean Medicine, Pusan National University, Yangsan, Gyeongnam, South Korea.
National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, Yangsan, South Korea.
Health Qual Life Outcomes. 2018 Nov 19;16(1):213. doi: 10.1186/s12955-018-1038-0.
Facial palsy is known to have correlations with low level of quality of life. However, little is known about the association between preference based health-related quality of life (HRQoL) and paralytic side of facial palsy.
This study used Korea National Health and Nutrition Examination Survey (KNHANES, 2008-2012) data, only when the facial palsy examination had been included in the survey contents. Hierarchical regression analyses were used to obtain optimal regression coefficients in the association between paralytic side of the facial palsy and HRQoL measured by EuroQoL-5 Dimension (EQ-5D). We also analyzed the association between the deteriorated domains of EQ-5D and facial palsy in both subgroups by using multiple logistic regression models.
We included the data of 28,106 participants aged ≥19 years who were examined as facial palsy according to House-Brackmann score and completed EQ-5D questionnaire in KNHANES 2008-2012. The mean EQ-5D score was significantly low and percentages of deteriorated numbers in its domains were significantly high in facial palsy group.
These results show that, after adjusting for confounding variables, left facial palsy is associated with impaired HRQoL compared with right-sided palsy. Among the domains of EQ-5D, only 'self-care' domain was directly affected by the disease in left facial palsy patients. These findings could be used in developing model and conducting analyses of economic evaluation about facial palsy interventions.
面瘫与生活质量水平降低有关。然而,面瘫的麻痹侧与基于偏好的健康相关生活质量(HRQoL)之间的关联知之甚少。
本研究使用了韩国国家健康和营养检查调查(KNHANES,2008-2012)的数据,仅在调查内容中包含面瘫检查时才使用这些数据。采用分层回归分析,以获得面瘫麻痹侧与 EuroQoL-5 维度(EQ-5D)测量的 HRQoL 之间关联的最佳回归系数。我们还使用多变量逻辑回归模型分析了 EQ-5D 恶化的各个领域与面瘫在两个亚组之间的关联。
我们纳入了 2008-2012 年 KNHANES 中根据 House-Brackmann 评分检查并完成 EQ-5D 问卷的 28106 名年龄≥19 岁的面瘫患者的数据。面瘫组的 EQ-5D 评分明显较低,其各领域恶化的比例明显较高。
这些结果表明,在校正混杂变量后,与右侧面瘫相比,左侧面瘫与 HRQoL 受损相关。在 EQ-5D 的各个领域中,只有“自我护理”领域在左侧面瘫患者中受到疾病的直接影响。这些发现可用于开发面瘫干预措施的经济评估模型和进行分析。