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[1例原发性肺滑膜肉瘤术后多发转移经阿帕替尼治疗的病例报告]

[A Case Report of Primary Pulmonary Synovial Sarcoma with Postoperative Multiple Metastases Treated with Apatinib].

作者信息

Zhang Di, Zhang Chufeng, Guo Qisen

机构信息

Shandong Cancer Hospital Affiliated to Shandong University, Shandong University, Jinan 250117, China.

Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Shandong Cancer Hospital 
and Institute, Jinan 250117, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2018 Nov 20;21(11):880-884. doi: 10.3779/j.issn.1009-3419.2018.11.11.

Abstract

Primary pulmonary synovial sarcoma is a rare pulmonary malignant tumor originated from primitive mesenchymal, which has short overall survival and poor prognosis. Related case reports are lacked at home and abroad. In recent years, the development of targeted therapy has brought remarkable benefits to cancer patients. Apatinib (Hengrui Pharmaceutical Co. Ltd, Jiangsu, People's Republic of China) is a small molecule vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which selectively inhibits VEGFR-2 and blocks the VEGF signal pathway, then strongly inhibiting the tumor angiogenesis. Apatinib has shown favorable therapeutic effect and acceptable toxicity on various tumors. Here we report a case of primary pulmonary synovial sarcoma with postoperative multiple metastases treated with apatinib, in order to provide a new considerable treatment.
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摘要

原发性肺滑膜肉瘤是一种罕见的起源于原始间充质的肺部恶性肿瘤,其总生存期短且预后差。国内外缺乏相关病例报道。近年来,靶向治疗的发展给癌症患者带来了显著益处。阿帕替尼(中国江苏恒瑞医药股份有限公司)是一种小分子血管内皮生长因子受体2(VEGFR-2)抑制剂,它选择性抑制VEGFR-2并阻断VEGF信号通路,从而强烈抑制肿瘤血管生成。阿帕替尼已在各种肿瘤中显示出良好的治疗效果和可接受的毒性。在此,我们报告一例原发性肺滑膜肉瘤术后多发转移患者接受阿帕替尼治疗的病例,以期提供一种新的可参考的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb7/6247001/2850f4180acd/zgfazz-21-11-880-1.jpg

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