Conti Bruno
Departments of Molecular Medicine and of Neuroscience, Dorris Neuroscience Center, Scripps Research Institute, La Jolla, CA, United States.
Handb Clin Neurol. 2018;156:129-133. doi: 10.1016/B978-0-444-63912-7.00008-4.
Classic lesion and physiology experiments identified the hypothalamic preoptic area as a pivotal region in the regulation of temperature homeostasis. The preoptic area can sense changes in local temperature, receives information about ambient temperature, contributes to fever, and can affect thermoregulation in response to several biologic signals. Electrophysiologic studies indicate that these actions are mediated by a neuronal circuitry that comprises temperature-sensitive as well as temperature-insensitive neurons. Little is known on the molecules that may be required for central thermosensation and much of the efforts towards their identification was done for warm-sensitive neurons. Here we summarize the current knowledge on the subject as well as what the search for these molecules revealed about warm-sensitive neurons.
经典的损伤和生理学实验确定下丘脑视前区是体温稳态调节的关键区域。视前区能够感知局部温度变化，接收有关环境温度的信息，引发发热，并能响应多种生物信号影响体温调节。电生理学研究表明，这些作用是由一个包含温度敏感神经元和温度不敏感神经元的神经回路介导的。对于中枢热感觉可能所需的分子，我们了解甚少，而且在识别这些分子方面所做的大部分工作是针对热敏神经元的。在这里，我们总结了关于这个主题的当前知识，以及寻找这些分子对热敏神经元的揭示。
