The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Emergency, Hunan Provincial People's Hospital, No. 61, Jefang West Road, Changsha, Hunan, China.
Department of Gastroenterology, 303 Hospital of People's Liberation Army, Nanning, Guangxi, China.
Biochem Biophys Res Commun. 2018 Nov 30;506(3):626-631. doi: 10.1016/j.bbrc.2018.10.051. Epub 2018 Oct 24.
Heat stroke is a serious pathological condition with high mortality. Vascular endothelial cell injury is a key feature in the pathogenesis of heat stroke, but the specific pathophysiological process whereby this occurs is still unclear. Currently, relevant studies are primarily based upon examination of apoptosis. Recently, pyroptosis, a new form of inflammation-related programmed cell death, was also demonstrated to be involved in heat stroke pathophysiology. Herein, we present evidence that vascular endothelial cell pyroptosis can be induced by heat stress in a time- and temperature-dependent manner. Furthermore, this process can be significantly inhibited by GSDMD siRNA. These findings suggest a new therapeutic target for heat stroke.
中暑是一种严重的病理状态，死亡率较高。血管内皮细胞损伤是中暑发病机制中的一个关键特征，但具体的病理生理过程尚不清楚。目前，相关研究主要基于细胞凋亡的检查。最近，细胞焦亡，一种新的炎症相关程序性细胞死亡形式，也被证明与中暑的病理生理学有关。在此，我们提供的证据表明，血管内皮细胞焦亡可以在时间和温度依赖的方式下由热应激诱导。此外，这一过程可以被 GSDMD siRNA 显著抑制。这些发现为中暑提供了一个新的治疗靶点。
