帕金森病患者丘脑底核深部脑刺激术后的发音困难和构音障碍：频率调制的影响。
Dysphonia and Dysarthria in People With Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation: Effect of Frequency Modulation.
机构信息
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
出版信息
J Voice. 2020 May;34(3):477-484. doi: 10.1016/j.jvoice.2018.10.012. Epub 2018 Nov 16.
PURPOSE
Subthalamic nucleus deep brain stimulation (STN-DBS) parameters, for example the frequency of stimulation, seem to affect speech and voice aspects. However, this influence is not well understood. This study aimed to investigate the impact of low- and high-frequency STN-DBS on voice and speech for people with Parkinson's disease.
METHODS
Nineteen individuals with Parkinson's disease who received bilateral STN-DBS were assessed for motor performance (Unified Parkinson's Disease Rating Scale-III), perceptual evaluation of voice (grade, roughness, breathiness, asthenia, strain, and instability [GRBASI]), dysarthria assessment, and computerized acoustic analysis of voice upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS.
RESULTS
In the GRBASI protocol, asthenia, and instability were significantly better at 130 Hz of stimulation. In the dysarthria evaluation, the phonation aspect, articulation, and grade of dysarthria showed deterioration at the same high-frequency condition. There was no significant difference for any vocal acoustic measures.
CONCLUSION
The high-frequency of STN-DBS may affect speech and voice differently, leading to an amelioration of the vocal production, but with adverse effects in the speech control.
目的
丘脑底核深部脑刺激（STN-DBS）的参数，例如刺激频率，似乎会影响言语和声音方面。然而，这种影响尚不清楚。本研究旨在调查低频率和高频率 STN-DBS 对帕金森病患者语音和言语的影响。
方法
19 名接受双侧 STN-DBS 的帕金森病患者接受了运动表现（帕金森病统一评定量表-III）、语音感知评估（等级、粗糙度、气息度、乏力度、紧张度和不稳定性[GRBASI]）、构音障碍评估以及语音计算机声学分析的评估，分别在接受低频率（60Hz）和高频率（130Hz）STN-DBS 时。
结果
在 GRBASI 方案中，在 130Hz 的刺激下，乏力和不稳定性明显更好。在构音障碍评估中，发音方面、发音和构音障碍的等级在相同的高频条件下显示出恶化。任何语音声学指标均无显著差异。
结论
STN-DBS 的高频可能会以不同的方式影响言语和声音，导致发声得到改善，但言语控制会产生不良影响。
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